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Interrogating AOP-Wiki knowledge as a network

Kane S;

Adverse outcome pathways (AOPs) represent a formalised knowledge framework for capturing mechanisms leading to toxicity.

AOPs are a key tool in the development of integrated approaches to testing and assessment (IATA) and AOP-Wiki is the main public repository of this knowledge.

The data available from this resource can be viewed as single linear AOPs and, while this representation is valuable, new emergent pathways and previously unknown relationships can be discovered if the AOPs are viewed as a network.

Kaptis is an application developed by Lhasa which allows users to store, search and edit AOP knowledge. A key feature is the functionality to visualise AOPs as AOP networks from a selected Key Event (KE).