Metabolite identification and analysis
Determining metabolic fate of chemicals within drug development
Identification and analysis of metabolic fate of a chemical substance and the associated potential toxicity of the parent compound, or its metabolites, is a critical aspect of drug development.
Metabolic understanding in early drug research can save time in drug development and enhance the late-stage drug survival rate.
Computational approaches for the prediction of metabolic fate have been developed to support early screening for metabolites and greater transparency and control over metabolic fate.
In-depth knowledge of metabolic transformations and filtering options within Meteor Nexus helps with structure elucidation of experimentally observed metabolites.
Analyse metabolite predictions
Meteor Nexus metabolic fate predictions are clearly presented and contain detailed supporting evidence associated with the biotransformations predicted.
Access metabolism knowledge
We continuously improve and add to the knowledge within Meteor Nexus, utilising both public and proprietary data, resulting in vast coverage of biotransformations.
The best of both worlds: combining a defined approach and read-across to predict skin sensitisation potency
New approach methodologies (NAMs) are non-animal methods – including in chemico/in vitro assays and in silico predictions – which are increasingly being …
We are delighted to announce our participation in the Animal-Free Safety Assessment for Cosmetics (AFSA) Masterclass. Launched in March 2023, this free, …
We are delighted to share our vital new article ‘Establishing best practice for the application and support of solubility purge factors’ which …