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Publications

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Date

Paper

Reactivities of N-Nitrosamines against Common Reagents and Reaction Conditions

  • Sep 2024
  • Nitrosamine impurity risk assessment

QMRF

Derek Nexus 6.4 Carcinogenicity QMRF

  • Sep 2024
  • Carcinogenicity assessment

QMRF

Derek Nexus version 6.4 Teratogenicity QMRF

  • Sep 2024

QMRF

Derek Nexus version 6.4 HERG QMRF

  • Sep 2024

QMRF

Sarah Nexus 4.0 Chromosome Damage QMRF

  • Sep 2024

QMRF

Sarah Nexus version 4.0 Mutagenicity QMRF

  • Sep 2024
  • In silico mutagenicity assessment

QMRF

Derek Nexus version 6.4 Chromosome damage QMRF

  • Sep 2024

QMRF

Derek Nexus version 6.4 Skin sensitisation QMRF

  • Sep 2024
  • Skin sensitisation assessment

Paper

A developmental and reproductive toxicity adverse outcome pathway network to support safety assessments

  • Aug 2024
  • Safety profiling in drug discovery

Paper

Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies

  • Jul 2024
  • Impurity and degradant control, Nitrosamine impurity risk assessment

Poster

Review of methods to generate genotoxicity information and their ability to provide insight into carcinogenicity risk assessments

  • Jul 2024
  • Carcinogenicity assessment, In silico mutagenicity assessment

Paper

Structuring expert review using AOPs: Enabling robust weight-of-evidence assessments for carcinogenicity under ICH S1B(R1)

  • Jun 2024
  • Carcinogenicity assessment

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  • Solution

  • Publication Type

  • Date

Paper

A developmental and reproductive toxicity adverse outcome pathway network to support safety assessments

  • Aug 2024
  • Safety profiling in drug discovery

Poster

Using an AOP network to make hazard predictions for developmental and reproductive toxicity

  • Mar 2024
  • Safety profiling in drug discovery

Poster

Enabling next generation carcinogenicity assessment

  • Mar 2024
  • Carcinogenicity assessment, In silico mutagenicity assessment, Safety profiling in drug discovery

Paper

Enhancing developmental and reproductive toxicity knowledge: A new AOP stemming from glutathione depletion

  • Oct 2023
  • Safety profiling in drug discovery

Paper

Federated learning for molecular discovery

  • Apr 2023
  • Safety profiling in drug discovery

Paper

Risk assessment in the 21st century: where are we heading?

  • Feb 2023
  • Carcinogenicity assessment, Safety profiling in drug discovery

Poster

Using shared knowledge to improve predictions of adverse drug reactions and support decision making

  • Sep 2022
  • Carcinogenicity assessment, Safety profiling in drug discovery

Paper

Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment

  • May 2022
  • Carcinogenicity assessment, Safety profiling in drug discovery

Poster

Using privacy-preserving federated learning to enable pre-competitive cross-industry knowledge sharing and improve QSAR models

  • Mar 2022
  • Data sharing, Safety profiling in drug discovery

Poster

Interrogating AOP-Wiki knowledge as a network

  • Mar 2022
  • Carcinogenicity assessment, Safety profiling in drug discovery

Paper

Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition

  • Feb 2022
  • Safety profiling in drug discovery

Paper

Employing an adverse outcome pathway framework for weight-of-evidence assessment with application to the ICH S1B guidance addendum

  • Oct 2021
  • Carcinogenicity assessment, Safety profiling in drug discovery
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