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26 October 2020

2020 Lhasa Limited Virtual Symposium: The Application of Adverse Outcome Pathways (AOPs) for Risk Assessment

Virtual Conference

The Application of Adverse Outcome Pathways for Risk Assessment

Lhasa Limited was pleased to host a virtual symposium made up of a series of 4 webinars.

The theme of Lhasa's 2020 virtual symposium was the application of adverse outcome pathways (AOPs).

Each webinar session associated with this event featured presentations from both a Lhasa Limited scientist and an industry based guest speaker.

Please see speaker and presentation details for each session below, followed by recordings and slides: 

Session 1  - 5th October 2020 - The application of adverse outcome pathways (AOPs) to improve risk assessments for development and reproductive toxicity (DART)

  • Guest speaker: Richard Currie, Principal Technical Expert at Syngenta
  • Guest speaker presentation title: Building quantitative AOPs of the DARTable genome to explore risks of developmental toxicity.
  • Lhasa speaker: Adrian Fowkes, Science Team Leader
  • Lhasa speaker presentation title: Creating a DART AOP network to enable improved decision-making during risk assessments.

Session 2 - 12th October 2020 - Application of adverse outcome pathways (AOPs) to support integrated approaches to testing and assessment (IATA)

  • Guest speaker: Jason O'Brien, Health Canada
  • Guest speaker presentation title: AOP and IATA Complimentary Frameworks to Modernize Chemical Risk Assessment.
  • Lhasa speaker: Steve Kane, Scientist
  • Lhasa speaker presentation title: Integration of adverse outcome pathways (AOP) with experimental data to support the assessment of carcinogenic risk.

Session 3 - 19th October 2020 - The potential utility of AOPs in the future of regulatory decision-making

  • Guest speaker: David Jones, Expert Pharmaco Toxicologist at MHRA
  • Guest speaker presentation title: A pharmaceutical assessor’s view on the utility of adverse outcome pathways.
  • Lhasa speaker: Susanne Stalford, Senior Scientist
  • Lhasa speaker presentation title: Exploiting AOPs as a framework to support ICH S1 risk assessments

 Session 4 - 26th October 2020 - Harnessing the potential of adverse outcome pathways in the assessment of genotoxicity

  • Guest speaker: Carole Yauk, Lead of the Genomics Laboratory at Health Canada
  • Guest speaker presentation title: Collaborative efforts leading to a growing genetic toxicology AOP network.
  • Lhasa speaker: Alex Cayley, Senior Scientist
  • Lhasa speaker presentation title: Combining knowledge and data on an AOP framework in order to take advantage of new and emerging methods in genotoxicity assessment.
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