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Innovate

Discover the latest innovations in computer-aided reasoning and information systems.

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A step towards animal-free developmental and reproductive toxicity safety assessments

Developmental and reproductive toxicity (DART) is a critical area of toxicology that is required to assess the impact of new chemicals on adult fertility and embryo development. Industries across the globe rely on DART assessments to safeguard human health, adhering to regulatory standards like those outlined in the ICH S5 (R3) guideline. However, the current […]

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10 frequently asked questions about Derek Nexus, answered

For over four decades, at Lhasa Limited we have been developing scientific software solutions that enable scientists to make informed decisions on the safety of drugs, chemicals and cosmetics. Our journey advanced significantly with the creation of Derek Nexus, an in silico expert knowledge-based toxicity prediction tool. As regulatory landscapes evolved and the push for

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Adverse Outcome Pathways; AOP; AOPs; Carcinogenicity; Expert Review; Computational Toxicology; New Approach Methodologies; Weight-of-Evidence; WoE, ICH S1B

Embracing new approach methodologies in carcinogenicity assessments

Do you need a transparent, scientifically robust, and reproducible weight-of-evidence approach for assessing for carcinogenicity? Then this scientific publication is for you. We are excited to share “Structuring Expert Review Using AOPs: Enabling Robust Weight-of-Evidence Assessments for Carcinogenicity Under ICH S1B(R1)”, which has been published in Computational Toxicology, as part of our Lhasa special issue,

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Insights from the Lhasa Limited and IPEC Europe Nitrites collaborative meeting

“The meeting provided an opportunity to share our common difficulties and discuss solutions to establish robust and accurate methods for analysing nitrites in excipients.”   We recently welcomed members of the Lhasa Nitrites data sharing consortium and IPEC Europe – European Excipients Association for the first face-to-face Nitrites meeting at the Lhasa Head Office. Hosted

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Supporting the safe use of CDB in skincare products using Derek Nexus

Supporting the safe use of CBD in skincare products using Derek Nexus

Cannabidiol (CBD) is gaining prominence as a sought-after ingredient in skincare and beauty formulations, thanks to its notable anti-inflammatory, antioxidant and anti-bacterial properties. Derived directly from the hemp plant, this compound is increasingly being used as an ingredient in skincare products, particularly for the management of various skin conditions like eczema, dermatitis and psoriasis. Despite

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Have you read this? Benchmarking In silico prediction of pharmaceutical degradation pathways

We are delighted to share our important new open access article: In silico prediction of pharmaceutical degradation pathways: A benchmarking study using the software program Zeneth. The paper, recently published in Organic Process Research & Development (OPRD) is authored by Lhasa Principal Scientist Rachel Hemingway, alongside industry expert co-authors from AstraZeneca, GSK, Pfizer, BMS, Amgen

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Safeguarding Pharmaceutical Development: The Importance of Early Risk Mitigation

Ensuring the safety and efficacy of active pharmaceutical ingredients (APIs) is of paramount importance. A critical aspect of this process involves the identification and mitigation of potentially mutagenic impurities, like nitrosamines. In this blog, we will explore the significance of risk mitigation at the early stages of API development and introduce a cutting-edge solution, Zeneth,

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Mitigating the risks of NDSRI’s through data sharing

At Lhasa, we believe in the transformative power of knowledge sharing as the driving force to support the global challenge of nitrosamine risk assessment. Through data sharing and industry collaboration, we empower members to further understand the risks associated with their potential nitrosamine impurities. The Vitic Complex Nitrosamines initiative, launched in 2021 in response to

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