Discuss

Building on the success of our recent webinar, How to establish acceptable intake (AI) limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs), we’re thrilled to present a follow-up that brings you closer to the insightful discussions that unfolded during the interactive Q&A session. In this blog, we’ve gathered questions posed during the webinar and curated written

We are delighted to announce that our paper ‘Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition’ has been selected as the best paper published in Reproductive Toxicology in 2022. The award winning-paper, authored by Lhasa Principal Scientist, Alun Myden, Senior Scientist, Emma White and Head

In our earlier instalments of the Lhasa blog, we have discussed the latest regulatory insights presented by the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), and Health Canada regarding acceptable intake limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs). Now, our focus zeroes in on the Enhanced Ames Test (EAT) and its

The U.S. Food and Drug Administration (FDA) recently took a significant step forward in safeguarding public health by issuing a new guidance titled “Recommended Acceptable Intake Limits for Nitrosamine Drug Substance Related Impurities (NDSRIs) Guidance for Industry.” This important update addresses concerns related to NDSRIs, a group of nitrosamine impurities found in numerous drug products,

Join us as we look back at the highly anticipated 4th instalment of the Pharmaceutical Industry and Regulators Symposium, held at the prestigious Auditório do Conselho Federal de Farmácia in Brasilia. Packed to capacity, this event was a resounding success, attracting industry experts and regulatory authorities across Brazil. What is the Pharmaceutical Industry and Regulators

We had a fantastic time at this year’s Society of Toxicology (SOT) in Nashville, Tennessee, where Principal Scientist, Dr. Martyn Chilton was shortlisted for two Best Overall Abstract awards!  Martyn was awarded ‘Top 10 Best Computational Toxicology Specialty Section (CTSS) Abstract’ and ‘Top 10 Best Risk Assessment Speciality Section (RASS) Abstract’ for his poster which

In November last year, we published a ground-breaking article to Chemical Research in Toxicology titled ‘What Makes a Potent Nitrosamine? Statistical Validation of Expert-Derived Structure–Activity Relationships’.   Within the paper, we show that certain structural features, when treated independently, have a statistically significant impact on the carcinogenic potency of nitrosamines. It is with great excitement that