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The evolving role of genotox assessments

Webinar recap: Industry and regulator perspectives on in silico genotoxicity assessment

In a recent Lhasa Limited webinar, experts from BfR (the German Federal Institute for Risk Assessment), Syngenta, and Lhasa came together to explore how in silico tools are being used to support genotoxicity assessments. The session delivered a thorough overview of how these advanced computational methods are applied in both regulatory and industry settings, focusing […]

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From forced degradation to innovation: Your Science of Stability 2025 conference recap

The Science of Stability (SoS) 2025 conference, recently held in Philadelphia, brought together leading experts from the pharmaceutical industry and academia. Co-hosted by Lhasa Limited and FreeThink Technologies, this year’s event was a hub for collaboration and discussions. Attendees consistently praised the conference’s thematic structure and unparalleled networking opportunities, with many reporting a significant ‘increase in knowledge surrounding stability

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Enhancing the Ames test for N-Nitrosamines: Key findings from a multi-sector study

Enhancing the Ames test for N-nitrosamines: Key findings from a multi-sector study

The ICH M7(R2) Guideline (2023) continues to recommend the bacterial reverse mutation assay (Ames test), conducted in accordance with OECD 471, as a primary tool for assessing the mutagenic potential of pharmaceutical impurities, including nitrosamines. While the Ames test is generally predictive of rodent carcinogenicity, concerns remain about its sensitivity under standard conditions, particularly when

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Life at Lhasa video 1

Advancing drug discovery though data-driven federated learning

A new paper, “Data-driven federated learning in drug discovery with knowledge distillation”, was recently published in Nature Machine Intelligence, the leading journal for Machine Learning and AI. It explores the potential for federated learning to advance drug discovery through secure, collaborative research, representing a major step forward in privacy-preserving machine learning.   What is Federated

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Blog image for how to overcome challenges in forced degradation studies with Zeneth

How to overcome the critical challenges faced in forced degradation studies

At Lhasa we know that there are many challenges involved in carrying out risk assessments for drug substances and drug products, to ultimately ensure a safe and effective product for patients. Forced degradation studies are essential in pharmaceutical development to assess drug stability and ensure product quality and safety. These studies help identify degradation pathways,

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Anvisa rdc 964/2025 update blog image of logo

Anvisa RDC 964/2025: What you need to know about the latest regulatory update

The Brazilian Health Regulatory Agency (Anvisa) has introduced RDC 964/2025, a new guidance that outlines in more detail the requirements for conducting forced degradation studies. This new regulation replaces RDC 53/2015, aligning the requirements for forced degradation studies with international (ICH) standards. By reacting to these regulatory changes, Lhasa has evolved our solution for predicting

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Richard Williams memorial award winner

Interview with Caitlin Maggs, winner of the 2024 Richard Williams Memorial Award

The 2024 Richard Williams Memorial Award was proudly presented during the 37th annual Industrial Genotoxicology Group (IGG) meeting in Cambridge last December. This prestigious award, created to honour Dr Richard Williams, celebrates exceptional scientific contributions while supporting early-career researchers in the field of genotoxicology. Last year’s winner, Caitlin Maggs, is a second-year PhD student at

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Where can N-Nitrosamine data support an alternative AI beyond the CPCA?

Where can N-Nitrosamine data support an alternative AI beyond the CPCA?

The recently published paper “Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes,” presents evidence for evolving the pharmaceutical industry’s approach to N-nitrosamine risk assessment. While the Carcinogenic Potency Categorisation Approach (CPCA) has provided a solid framework for managing N-nitrosamine drug substance-related

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Sarah Nexus frequently asked questions

Everything you need to know about Sarah Nexus

The use of in silico prediction systems has become an essential part of regulatory submissions when assessing the genotoxic potential of chemicals. Guidelines such as those from the EMA, US FDA, and ICH highlight their importance. Most notably, the ICH M7 guidance explicitly requires the application of two complementary quantitative/qualitative structure-activity relationship ((Q)SAR) systems to

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