This publication highlights how Lhasa Limited in silico solutions enable confident, science-led toxicity assessments through the combined strengths of Derek Nexus and Sarah Nexus. Built on over 40 years of collaborative scientific research and developed alongside regulators and industry experts, these complementary systems integrate expert rule-based knowledge with advanced statistical modelling to support robust, transparent, and defensible decision-making.
Together, Derek Nexus and Sarah Nexus provide broad coverage across toxicity endpoints, including mutagenicity and genotoxicity, supporting compliance with global regulatory frameworks such as ICH M7, ISO 10993, OECD QAF, and EFSA guidance. Their outputs are designed to enhance interpretability, offering clear insight into prediction rationale, uncertainty, and supporting evidence, empowering scientists to understand not just the outcome, but the reasoning behind it.