Vitic
Your Chemical Toxicity Database
Achieving expert assessments, regardless of industry, with a centralised chemical toxicity database which offers a single source of truth.
Unlock the benefits of a centralised source of truth with our drug chemical database.
Navigating different sources of toxicity data across multiple novel and established compounds for regulatory submissions can be complex and time consuming since this involves reviewing, collating, and interpreting toxicity risks.
Our in-silico toxicity solution, the Vitic database from Lhasa Limited, is the endpoint database populated with regulatory, public, and proprietary chemically intelligent toxicity data. This tool creates a centralised, single source of robust chemical safety data, which enables confident and quick decision-making. But how?
Our solution
We offer Vitic, a structure-searchable chemical toxicity database that fuels its users with high-quality insights. The datasets are also pivotal to predictive models and read-across solutions. Discover how the Vitic database from Lhasa can facilitate efficient risk assessments across various applications:
In silico mutagenicity assessments with Vitic
Access expertly curated and peer reviewed mutagenicity and carcinogenicity data
Our regularly updated toxicity database offers high-quality, Lhasa-curated data. To maintain accuracy between Vitic data and the original data source, data is extracted manually by our scientists and peer reviewed by a second member of the science team.
A fast and efficient searching experience for accelerated ICH M7 classification of Class 1, 2 and 5
Rapidly find relevant supporting Ames test datasets for you specific impurity. Readily available, defensible bacterial mutagenicity data can offer an efficient Class 2 impurity, a known mutagen, or Class 5, non-mutagen. Vitic also includes mutagenic carcinogen insights from rodent bioassays for Class 1 impurities.
Collaborate with industry experts through data sharing
Lhasa-hosted data sharing initiatives, including the aromatic amines, excipients and complex nitrosamines consortia, allow anonymous sharing of mutagenicity data. These consortia avoid the need for duplicate testing and allow members to exchange knowledge with other industry experts through recurrent consortium meetings.
Carcinogenicity assessments using a chemical structure database
Search for data within other related endpoints
Alongside carcinogenicity data, you can also search for data within other related endpoints such as mutagenicity and chromosome damage, which can help to build your understanding of a carcinogenic risk.
Find similar structural analogues using substructure or similarity searches
Where there is no exact match within Vitic, you can make use of the substructure or similarity search functionality, helping you expand your research possibilities.
Genotoxic impurity evaluations and the Vitic database
Explore hundreds of in vivo and in vitro genetic toxicology study records
Vitic contains a wealth of high-quality carcinogenicity and genotoxicity data to support chemical risk assessments. This broader scope allows for a more complete assessment of your impurities, helping you evaluate their safety with confidence.
Skin sensitisation using a chemical toxicity database
Explore high-quality supporting data
Access both in vivo skin sensitisation data and data from New Approach Methodologies (such as in chemico /in vitro assays etc.). With new data added on a regular basis, users of Vitic can access current skin sensitisation data to support predictions and read-across assessments.
Non-genotoxic impurities
Search for data across a broad range of endpoints
Vitic is a database that contains toxicity data for endpoints beyond carcinogenicity and genotoxicity such as acute toxicity, skin sensitisation, irritation and developmental and reproductive toxicity. Access the toxicological data required to establish permissible daily exposures (PDEs), which can help to assess the broader toxicity of your impurities.