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    Regulatory Toxicology and Pharmacology
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    JUN 2022
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Updating the Dermal Sensitisation Thresholds using an expanded dataset and an in silico expert system

Chilton ML; Api AM; Foster RS; Gerberick GF; Lavelle M; Macmillan DS; Na M; O'Brien D; O'Leary-Steele C; Patel ML; Ponting DJ; Roberts DW; Safford RJ; Tennant RE;

Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used to justify exposure-based waiving when conducting a skin sensitisation risk assessment. This paper aimed to update the published DST values by expanding the size of the Local Lymph Node Assay (LLNA) dataset upon which they are based, whilst assigning chemical reactivity using our in silico expert system, Derek Nexus.

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