The Liability Load and how Lhasa Limited Focuses on Reducing it
The Liability Load is a concept which is highly relevant to mutagenicity assessment. The liability load as described by Jolly et al. includes the number of compounds that must be submitted for mutagenicity testing due to a failure of an in silico assessment to unambiguously mitigate uncertainty with respect to their mutagenic potential.
Lhasa Limited has taken a number of steps to lower the liability load when using its ICH M7 solutions and this graphic describes how.