Lhasa Limited shared knowledge shared progress
  • Highlighted Item:
  • Webinar:
  • Publisher:
    ACS Publications
  • Publication Date:
    May 2015
  • Reference:
    Chem. Res. Toxicol.
  • DOI:
  • PMID:
  • Publication Type:
  • Related Products:
  • Scientific Area:
  • Endpoint:
  • Industry Type:
  • Related event:

Relationship between the mutagenicity of arylboronic acids and 11B NMR chemical shifts

Covey-Crump E; Fisher J; Pellizzaro ML; Werner AL; Williams RV;

The mutagenicity of arylboronic acids has recently become an important area of research because of their potential to be genotoxic impurities in active pharmaceutical ingredients. There is no known mechanism, so currently all structure-activity relationships have been derived using Ames test data. We have shown that the mutagenicity of arylboronic acids is related to the 11B NMR chemical shift. This could indicate that the activity of the arylboronic acids is related to the reactivity of the boron centre.

Visit site

Additional Documents

    © 2022 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
    VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

    Apart from the free survey software, we also have access to QuestionPro's free survey templates . We've found many of them useful and powerful to collect insights from various stakeholders of our organization.