Lhasa Limited shared knowledge shared progress
Publications
  • Highlighted Item:
  • Publisher:
    Elsevier
  • Publication Date:
    Jan 2017
  • Reference:
  • DOI:
    10.1016/j.drudis.2017.01.001
  • PMID:
  • Publication Type:
    Paper
  • Related Products:
  • Scientific Area:
  • Endpoint:
  • Industry Type:
  • Related event:

Quantifying confidence in the reporting of metabolic biotransformations

Ponting DJ; Murray E; Long A;

How confident can we be in the assignment of metabolite structures? Are the analytical techniques used sufficient to support hypotheses about what is being formed? In this Feature, we discuss the results of an extensive survey into the analytical techniques used, and their value in the characterisation of metabolites. The survey covers the structures of over 16 000 metabolites formed from 1732 query compounds, covering over 35 years of the literature and a variety of journals. The value of different characterisation techniques is considered, alongside or in the absence of synthetic standards. The changes in analytical techniques used over time are briefly considered, and a metric for the confidence that a claimed metabolite has been confirmed is proposed.

 

Download

© 2020 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

Thanks to QuestionPro's generosity, we now have survey software that powers our data intelligence.