QSAR 2021 Is the bacterial reverse mutation assay an accurate predictor for N-nitrosamine carcinogenicity
Dr. David Ponting, Lhasa Senior Scientist presented this poster titled "Is the bacterial reverse mutation assay an accurate predictor for N-nitrosamine carcinogenicity?" at the International Workshop on (Quantitative) Structure-Activity Relationships in Environmental and Health Sciences. This poster focuses on Lhasa’s use of extensive data, curated in Vitic to investigate claims in older literature that the Ames test may not be adequate for nitrosamine carcinogenicity.
- Use of less-than-lifetime (LTL) durational limits for nitrosamines: Case study of N-Nitrosodiethylamine (NDEA)
- Utilisation of parametric methods to improve percentile-based estimates for the carcinogenic potency of nitrosamines
- Are all nitrosamines concerning? A review of mutagenicity and carcinogenicity data