Lhasa Limited shared knowledge shared progress
Publications
  • Highlighted Item:
  • Publisher:
  • Publication Date:
  • Reference:
  • DOI:
  • PMID:
  • Publication Type:
    Poster
  • Related Products:
  • Scientific Area:
  • Endpoint:
  • Industry Type:
  • Related event:

Prediction of microvesicular liver steatosis: Read-across case study with VPA analogues

pdf fileGrapel R; Tluczkiewicz I; Abdelaziz A; van de Burg B; van de Water B; Fisher C; Aguayo A; Bischoff L; Hengstler J; Escher S; Maclennan R; Exner T; Norinder U; Taboureau O; Drewe WC; Long A; Hatley O; Pawar G; Ecker G; Bois F; Jennings P; Stober R; Goldmann D; Gautier F; Limonciel A; Lindberg J; Braunbeck T; Tebby C; Moritz W; Kelm J; Brotzmann K;

This case study aims to develop non-animal approaches which can be used to reduce the uncertainty of read across predictions. Valproic acid (VPA), a short-branched carboxylic acid, was selected as the lead compound for this case study. VPA is used in the treatment of epilepsy in humans and induces microvesicular hepatic steatosis in the liver of some patients. In this read-across case study, it is investigated whether the EU-ToxRisk in silico and in vitro models predict the in vivo potential of VPA analogues to induce microvesicular steatosis, qualitatively and quantitatively.

Download

Related Publications

© 2020 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

Thanks to QuestionPro's generosity, we now have survey software that powers our data intelligence.