Predicting N-Nitrosamine Activity from SAR
This presentation was presented by Kevin P. Cross, PhD (Instem PLC) at QSAR 2021 and describes Lhasa and Instem's collaborative efforts in the area of N-nitrosamine assessment, including the nitrosamine SAR working group - currently comprising of 23 companies and universities.
- Use of Structure Activity Relationship (SAR) Evaluation as a Critical Tool in the Evaluation of the Genotoxic Potential of Impurities
- Utilisation of parametric methods to improve percentile-based estimates for the carcinogenic potency of nitrosamines
- QSAR 2021 Is the bacterial reverse mutation assay an accurate predictor for N-nitrosamine carcinogenicity