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    ACS Publications
  • Publication Date:
    JUL 2021
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    Org. Process Res. Dev. 2021, 25, 8, 1788–1801
  • DOI:
    https://doi.org/10.1021/acs.oprd.1c00162
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    Paper
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Nitrosamine Reactivity: A Survey of Reactions and Purge Processes

Borths CJ; Burns MJ; Curran T; Ide ND;

Abstract
Drug recalls have led to increased regulatory scrutiny into the formation and presence of nitrosamine (N-nitrosoamine) impurities in medicines. This review aims to assist the development of risk mitigation strategies by summarizing known reactions of nitrosamines, with a focus on reactions useful within the context of complex molecule synthesis. This review should serve as a useful reference and help lead to the development of chemical processes which effectively control nitrosamines.

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