Lhasa Limited shared knowledge shared progress
Publications
  • Publisher:
    ACS Publications
  • Publication Date:
    Oct 2014
  • Reference:
    Mol. Pharmaceutics, 2014, 11(11), pp4179-4188
  • DOI:
    10.1021/mp5003976
  • PMID:
  • Publication Type:
    Paper
  • Related Products:
  • Scientific Area:
  • Endpoint:
  • Industry Type:
  • Related event:

In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study

Alsante KM; Baertschi SW; Foti C; Kleinman MH; Mowery MD; Nefliu M; Ott MA; Reid DL; Reynolds DW; Shimanovich R; Smith WK;

Zeneth is a software application capable of predicting degradation products derived from small molecule active pharmaceutical ingredients. This study was aimed at understanding the current status of Zeneth’s predictive capabilities and assessing gaps in predictivity. Using data from 27 small molecule drug substances from five pharmaceutical companies, the evolution of Zeneth predictions through knowledge base development since 2009 was evaluated. The experimentally observed degradation products from forced degradation, accelerated, and long-term stability studies were compared to Zeneth predictions.

Visit site

© 2019 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

Thanks to QuestionPro's generosity, we now have survey software that powers our data intelligence.