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How low can you go? An analysis of lowest effective dose in the Ames test.

pdf fileKocks G; Tate M; Williams RV; Rawlinson P;

The food industry requires risk assessments to be performed on all substances migrating from Food Contact Articles (FCAs) and Food Contact Materials (FCMs). This includes non-intentionally added substances (NIAS), which often form a significant part of the overall migrate. Genotoxicity risk assessments strongly rely on the availability of information but the unknown properties of NIAS present a significant challenge.

Performing in vitro assay testing might prove difficult, partly due to questions regarding which test methods provide sufficient sensitivity and if the small amount of migrate produced is insufficient for toxicological testing. The results of in vitro tests could potentially be used to assess FCM migrant’s potential to cause  toxicological hazard.

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