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Developing Structure-Activity Relationships for the Prediction of Hepatotoxicity

Fisk L; Greene N; Naven RT; Note RR; Patel ML; Pelletier DJ;

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems. This process can be supported by the use of existing toxicity data and mechanistic understanding of the biological processes for related compounds. 

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