Developing structure-activity relationships for N-nitrosamine activity
In this paper, Dr. Kevin Cross from Instem and Lhasa Principal Scientist, Dr. David Ponting investigate whether improvements in SARs can more accurately predict N-nitrosamine carcinogenic potency.
A working group of 23 companies and universities was established with the goals of addressing several scientific and regulatory issues and improved methods for calculating acceptable intake limits for N-nitrosamines based upon mechanistic analogs. Kevin & David describe this collaboration and review their current progress towards development of mechanistically based structure–activity relationships.
If you're interested in complex nitrosamines, you may enjoy Lhasa Principal Application Scientist, Fernanda Waechter's video below which mentions this publication.