Lhasa Limited shared knowledge shared progress
Publications

Comparing and combining in silico outcomes and in vitro mechanism-based assays to predict genotoxicity

pdf fileStalford SA; Cayley A; Derr R; Hendriks G;

Genotoxicity is of major concern in human health risk assessment, and as such, regulatory guidance across a diverse number of industries calls for extensive genotoxicity testing to be carried out on new chemical entities. As there is an ambition to abolish in-vivo experiments when assessing safety, in-vitro assays have also been incorporated into regulatory decision making. (Q)SAR and high-throughput assays can provide valuable information about mechanism of action and can be considered as alternatives, or add context to traditional regulatory assays. However, how do these technologies compare in terms of activity prediction, and can their results be combined to give a better overall prediction for genotoxicity?

Download

Additional Documents

    © 2021 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
    VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

    Apart from the free survey software, we also have access to QuestionPro's free survey templates . We've found many of them useful and powerful to collect insights from various stakeholders of our organization.