- Publisher:Journal of Chemical Information & Modeling - ACS Publications
- Publication Date:Jan 2010
- Reference:J. Chem. Inf. Model., 2010, 50 (2), pp 274–297
- Publication Type:Paper
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An in Silico Method for Predicting Ames Activities of Primary Aromatic Amines
In this paper, the authors describe an in silico first principal approach to predict the mutagenic potential of primary aromatic amines. This approach is based on the so-called “nitrenium hypothesis”, which was developed by Ford et al. in the early 1990s.