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  • Publisher:
    Chemical Research in Toxicology
  • Publication Date:
    May 2022
  • Reference:
  • DOI:
    10.1021/acs.chemrestox.2c00031
  • PMID:
  • Publication Type:
    Paper
  • Related Products:
  • Scientific Area:
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    Skin
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An Evaluation of the Occupational Health Hazards of Peptide Couplers

Graham JC; Trejo-Martin A; Chilton ML; Kostal J; Bercu JP; Beutner GL; Bruen US; Dolan DG; Gomez S; Hillegass J; Nicolette JJ; Schmitz M;

This scientific paper evaluates the occupational health hazards of 25 commonly used peptide couplers and a select group of their hydrolysis products for in vivo, in vitro, and in silico testing.

The study demonstrates the merits of an integrated, in vivo -in silico analysis, applied to the skin sensitisation endpoint using Computer-Aided Discovery and REdesign (CADRE) and Derek Nexus.

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