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Publications

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Date

Paper

Reactivities of N-Nitrosamines against Common Reagents and Reaction Conditions

  • Sep 2024
  • Nitrosamine impurity risk assessment

QMRF

Derek Nexus 6.4 Carcinogenicity QMRF

  • Sep 2024
  • Carcinogenicity assessment

QMRF

Derek Nexus version 6.4 Teratogenicity QMRF

  • Sep 2024

QMRF

Derek Nexus version 6.4 HERG QMRF

  • Sep 2024

QMRF

Sarah Nexus 4.0 Chromosome Damage QMRF

  • Sep 2024

QMRF

Sarah Nexus version 4.0 Mutagenicity QMRF

  • Sep 2024
  • In silico mutagenicity assessment

QMRF

Derek Nexus version 6.4 Chromosome damage QMRF

  • Sep 2024

QMRF

Derek Nexus version 6.4 Skin sensitisation QMRF

  • Sep 2024
  • Skin sensitisation assessment

Paper

A developmental and reproductive toxicity adverse outcome pathway network to support safety assessments

  • Aug 2024
  • Safety profiling in drug discovery

Paper

Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies

  • Jul 2024
  • Impurity and degradant control, Nitrosamine impurity risk assessment

Poster

Review of methods to generate genotoxicity information and their ability to provide insight into carcinogenicity risk assessments

  • Jul 2024
  • Carcinogenicity assessment, In silico mutagenicity assessment

Paper

Structuring expert review using AOPs: Enabling robust weight-of-evidence assessments for carcinogenicity under ICH S1B(R1)

  • Jun 2024
  • Carcinogenicity assessment

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  • Solution

  • Publication Type

  • Date

Paper

A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure–activity alert spaces

  • Feb 2017
  • Skin sensitisation assessment

Paper

Quantifying confidence in the reporting of metabolic biotransformations

  • Jan 2017
  • Metabolite identification and analysis

Paper

Applicability domain: towards a more formal definition

  • Nov 2016
  • In silico mutagenicity assessment

Paper

Management of pharmaceutical ICH M7 (Q)SAR predictions – The impact of model updates 

  • Nov 2016
  • In silico mutagenicity assessment, Toxicity assessment of impurities

Paper

A k-Nearest Neighbours Approach Using Metabolism-related Fingerprints to Improve in Silico Metabolite Ranking 

  • Oct 2016
  • Metabolite identification and analysis

Infographic

How Meteor Nexus Predicts

  • Jul 2016
  • Metabolite identification and analysis

Paper

Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assays

  • Apr 2016
  • Skin sensitisation assessment

Paper

Impact from the Recent Issuance of ANVISA Resolution RDC-53/2015 on Pharmaceutical Small Molecule Forced Degradation Study Requirements

  • Mar 2016
  • Impurity and degradant control

Paper

It’s difficult, but important, to make negative predictions

  • Jan 2016
  • In silico mutagenicity assessment

Paper

Establishing best practise in the application of expert review of mutagenicity under ICH M7

  • Aug 2015
  • In silico mutagenicity assessment

Paper

Mutagenic Impurities: Precompetitive/Competitive Collaborative and Data Sharing Initiatives

  • May 2015
  • Data sharing, Impurity and degradant control, In silico mutagenicity assessment

Paper

Assessing Confidence in Predictions Using Veracity and Utility – A Case Study on the Prediction of Mammalian Metabolism by Meteor Nexus

  • Apr 2015
  • Metabolite identification and analysis
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