Chat with us, powered by LiveChat
Lhasa Logo

Publications

Read our latest publications

Filter by:

Solution

Publications Specific Solution Area

Publication Type

Date

Paper

Reactivities of N-Nitrosamines against Common Reagents and Reaction Conditions

  • Sep 2024
  • Nitrosamine impurity risk assessment

QMRF

Derek Nexus 6.4 Carcinogenicity QMRF

  • Sep 2024
  • Carcinogenicity assessment

QMRF

Derek Nexus version 6.4 Teratogenicity QMRF

  • Sep 2024

QMRF

Derek Nexus version 6.4 HERG QMRF

  • Sep 2024

QMRF

Sarah Nexus 4.0 Chromosome Damage QMRF

  • Sep 2024

QMRF

Sarah Nexus version 4.0 Mutagenicity QMRF

  • Sep 2024
  • In silico mutagenicity assessment

QMRF

Derek Nexus version 6.4 Chromosome damage QMRF

  • Sep 2024

QMRF

Derek Nexus version 6.4 Skin sensitisation QMRF

  • Sep 2024
  • Skin sensitisation assessment

Paper

A developmental and reproductive toxicity adverse outcome pathway network to support safety assessments

  • Aug 2024
  • Safety profiling in drug discovery

Paper

Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies

  • Jul 2024
  • Impurity and degradant control, Nitrosamine impurity risk assessment

Poster

Review of methods to generate genotoxicity information and their ability to provide insight into carcinogenicity risk assessments

  • Jul 2024
  • Carcinogenicity assessment, In silico mutagenicity assessment

Paper

Structuring expert review using AOPs: Enabling robust weight-of-evidence assessments for carcinogenicity under ICH S1B(R1)

  • Jun 2024
  • Carcinogenicity assessment

Filter by:

  • Solution

  • Publication Type

  • Date

Paper

Leveraging ICH M7 Control Options 3 and 4: Discussion and Clarification Using Industrial Case Studies

  • Jul 2024
  • Impurity and degradant control, Nitrosamine impurity risk assessment

Paper

In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth

  • Feb 2024
  • Impurity and degradant control

Infographic

Control your PMIs with Mirabilis and save an estimated $1.35M annually

  • Jul 2023
  • Impurity and degradant control

Paper

Identifying the risk of formation of nitrosamines and other potentially mutagenic impurities during API manufacture using in-silico risk assessment

  • Jun 2023
  • Impurity and degradant control

Poster

A machine-learned Bond Dissociation Enthalpy model to support predictions of forced degradation

  • May 2023
  • Impurity and degradant control

Paper

Development of the Methodology for in Silico Reactivity-Based Purge Predictions: Making Mirabilis Think Like a Chemist

  • Mar 2023
  • Impurity and degradant control

Paper

Establishing Best Practice for the Application and Support of Solubility Purge Factors

  • Mar 2023
  • Impurity and degradant control

Poster

Predicting Generation of Potential Mutagenic Impurities within Mirabilis using the Condition Approach

  • Jun 2022
  • Impurity and degradant control, Nitrosamine impurity risk assessment

Poster

A knowledge based in silico system to aid prediction of N-nitrosamine degradants in organic compounds that contain a vulnerable amine moiety

  • Jun 2022
  • Impurity and degradant control, Nitrosamine impurity risk assessment

Book chapter

Chapter 9: Mutagenic Impurities – Assessment of Fate and Control Options

  • Feb 2022
  • Impurity and degradant control

Book chapter

Chapter 7: Compound- and Class-Specific Limits for Common Impurities in Pharmaceuticals 

  • Feb 2022
  • Data sharing, Impurity and degradant control, Toxicity assessment of impurities

Book chapter

Chapter 3: Control Strategies for Mutagenic Impurities

  • Feb 2022
  • Impurity and degradant control, Toxicity assessment of impurities
Get in touch
Lhasa Logo

Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK
Tel: +44 (0)113 394 6020

Sign up to our newsletter

Name(Required)
Hidden
GDPR Compliant
Hidden
Hidden
Hidden
Hidden
Hidden
DD slash MM slash YYYY
This field is for validation purposes and should be left unchanged.

© 2024 Lhasa Limited, All rights reserved | Company registration number: 01765239 |
VAT number: 396 8737 77 | Registered charity number: 290866 | Governing documents

Connect with us

Linkedin-in Instagram