Lhasa Limited Releases New Data into its Carcinogenicity Database
Date: 27 January 2020
Leeds, UK, 27/01/20 – Lhasa Limited, an educational charity which creates state-of-the-art in silico prediction and database systems, releases new data into its Carcinogenicity Database.
Released in 2016 and founded on the recently retired Carcinogenic Potency Database (CPDB), the Lhasa Carcinogenicity Database (LCDB) is a vital source of long-term carcinogenicity study data. Free to use and easily accessible online, the database is a structure searchable repository of 7,745 long-term carcinogenicity studies covering 1,726 chemicals, of which 141 contain a nitrosamine group. The LCDB is a valuable resource for those that may have previously relied upon the CPDB for accessing carcinogenicity potency data.
Lhasa Limited understood the importance of the CPDB resource, particularly for the generation of acceptable limits as part of chemical risk assessments. Recognising the risk that the unmaintained resource may not persist, Lhasa acted to secure and maintain the data, creating a more usable platform in the process. Lhasa’s creation of the LCDB has secured the public benefit that the CPDB offered and builds on the excellent work of those involved in its development. Not only does the Lhasa Carcinogenicity Database contain the original CPDB data, it has also been updated to include Lhasa’s own reproducible potency calculations1. Lhasa is now excited to share the latest advancements to the LCDB.
Since the last release of CPDB in 2007, 197 new chemical structures have been assessed for carcinogenicity by the NTP, and this data has now been added to the LCDB. Lhasa Limited have also generated TD50s for this data so that they can be used to set acceptable limits as part of a risk assessment. As an invaluable resource, Lhasa is committed to maintaining the LCDB and encourages collaboration and suggestions for improvements.
You can find out more about the LCDB in an upcoming webinar on accessing carcinogenicity potency data. Lhasa Limited Chief Scientific Officer, Richard Williams, Senior Scientist, Andrew Thresher, and Product Manager, Nik Marchetti, will discuss accessing carcinogenicity potency data in a free to attend webinar on the 4th February 2020. For more information or to register for the event, please visit our events page.
- Thresher T, Gosling J P, Williams R. Generation of TD50 values for carcinogenicity study data. Toxicology Res., 2019, 8, 696-703
Potential disruption to service on 27th January: Please note that there may be some disruption to service whilst the Lhasa Carcinogenicity Database is updated. This disruption is expected to last no longer than 1 hour.