Lhasa Limited shared knowledge shared progress

Charitable statement

Public Benefit

The Lhasa Limited board of Directors holds in high regard the principle of public benefit and requires the Chief Executive Officer and staff of Lhasa Limited to pursue strategies that demonstrate this.  The Board of Directors, at its quarterly meetings, reviews ongoing charitable activities to ensure consistency with our charitable objects.  The Board of Directors is aware of the Charity Commission’s guidance on public benefit and has regard to it in determining the charity’s aims and in the way it carries out its activities.

Lhasa Limited is committed to the development and use of computer-aided reasoning and information systems for the advancement of chemistry and the life sciences. By performing research on chemical, toxicology and metabolism data, our scientists are able to provide members with software systems that allow them to make predictions about the safety of chemicals, thereby providing public benefit through:

  • Reducing the need for animal testing
  • Improving the lengthy and costly process of developing new drugs
  • Safeguarding human health from the adverse effects of chemicals

Aims

The charitable aims of Lhasa Limited include the sponsorship of activities that advance scientific knowledge and understanding through the use of computer-aided reasoning in chemistry and the life sciences. The Charity directly promotes and encourages the use of our software for academic teaching and research by offering membership on significantly preferential terms. In addition, the Charity actively supports research through sponsorship of:

  • Computational chemistry events
  • Scientific symposia and academic prizes
  • Research projects and scientific training to Ph.D. level

As well as performing research and development ourselves, the Charity is committed to providing financial support for others to carry out their own research and to discuss their findings to further advance and refine the science. Specifically, the Charity provides support for research within academic institutions and the outcomes of this research and that of our own scientists, are disseminated through publications, talks and poster presentations at relevant scientific events all around the world.

The software developed by the Charity enables the scientific community to carry out research much more effectively, reducing animal use in experiments, helping to improve toxicological testing and improving the communication of knowledge about toxicology and metabolism. Members, academic and government regulatory organisations benefit from the unique data and knowledge-sharing approach of Lhasa Limited, enhancing quality of life by assisting in the development of, and access to, safer chemical entities for the benefit of the public. 

Position

Our position as a charity, without a purely commercial outlook, makes it easier for organisations to donate their data, secure in the knowledge that it will only be used to promote scientific development to the benefit of all. In addition, our unique position is seen as key for sharing contributed data (for example our role in the eTOX consortium where we hold the position of “honest broker”), which further expands the scope of scientific collaboration for the public benefit.

Membership and software sponsorship fees are used to support the ongoing research and development carried out by the Charity. Through the generous funding of our main sponsors, Lhasa Limited is able to offer very low fees to academic organisations and public non-political bodies to ensure that its knowledge is available to the widest possible public audience. In addition, members contribute the results of their own research, thereby making scientific research publicly available that would not otherwise be accessible to the scientific community. The Charity therefore plays an invaluable role by bringing previously unpublished information into the public domain, and permitting the knowledge derived from this to be used by the scientific community for the public benefit.

Key Examples

USA Federal Drug Administration Research Collaboration Agreement

The FDA RCA (Research Collaboration Agreement) allowing the data shared by the FDA with Lhasa Limited to continue to aid the development of our Derek Nexus, Meteor and Vitic software progressed well during 2012. This project benefits the outputs of computer-aided reasoning in chemistry and the life sciences in accordance with our charitable objects.

OECD Toolbox Phase II

Lhasa Limited, having been invited as part of a consortium to participate in an open tender by the European Chemical Hazards Agency (ECHA) in association with the Organisation of Economic Cooperative Development (OECD), was formally recognised as a partner in the project on 18 December 2008. Since that time Lhasa Limited has made available key researchers to explore toxicological pathways to support the development of the Toolbox. This project came to a close in October 2012 and continues to deliver successful outcomes for publicly available software in support of the prediction of the activity of chemicals in the environment, as part of the chemicals registration process overseen by ECHA.

IMI - eTOX Project

Working as part of a consortium of 15 European pharmaceutical companies and 10 SME/Academic partners, Lhasa Limited is providing database and toxicology skills with the objective of improving in silico prediction of toxicology and pharmacology. This project officially began in January 2010 and we are continuing to provide support for the programme, with a specific focus on our role as host of the public  and confidential data that are being shared as the cornerstone of this project.

IMI – MIP DILI Project

Working as part of a consortium of 11 European pharmaceutical companies, 5 SME organisations and 9 universities, Our core role in the eTOX project led to a request for Lhasa Limited to participate in this project with the objective of improving in vitro prediction of toxicology and pharmacology associated with the liver. This project officially began in March 2012 and our role is to act as host of the public and confidential data that are being shared in this project.

Intermediates data sharing

The Intermediates data sharing project initiated in 2006 produced its first release in June 2007 using the Vitic software. The project continues to add data records covering areas of interest to the participating members and enabling predictions to be made about production intermediates that improve the safety of products without the need for additional testing. During the latter part of 2011 the project was expanded to cover the provision and sharing of data for aryl boronic acids and aromatic amines, thus continuing to make available additional information vital for the understanding of the toxicity of intermediate impurities.

Excipients data sharing

This data sharing project began in 2008 following the selection of Lhasa Limited and our Vitic software by an industry group whose focus was the sharing of test data with the primary aim of reducing animal testing. Lhasa Limited continued to promote this group and has had further success in widening participation during 2012.

Sponsorship

Sponsorship expenditure during 2012 totalled £165,322. During 2012 the Board of Directors approved a number of sponsorship activities in accordance with Lhasa Limited’s charitable objects including:

  • The 2012 Toxicology Module Prize in the School of Biomedical Sciences at the University of Leeds
  • Patronage of the ISSX
  • The African Education Initiative in which the participation of 7 African students in the toxicology programme was enabled by Lhasa Limited sponsorship.
  • Continued funding of the Chemical Bioactivity Information Centre (formerly the Judson Foundation) for the promotion of the use of computer aided reasoning and toxicology in Africa
  • World Congress on Alternatives to Animal use in Life Sciences, Japan
  • Sponsorship of the AltTox.org e-newsletter
  • The sponsorship of a PhD student at the University of Cambridge looking at transporter mediated metabolism which is expected to conclude in 2014
  • A post-doctoral research project with the University of Copenhagen investigating reactivity models for metabolism prediction
  • The sponsorship of a PhD student at the University of Bradford looking at the influence of formulation on toxicity
  • Knowledge Transfer Programme at the University of Sheffield commenced in January 2011 applying and developing the knowledge gained within the PhD previously sponsored by Lhasa Limited. This project has made excellent progress during 2012 and has also made a contribution to Lhasa Limited knowledge development during 2012. This project concluded in March 2013.

Contact Us

© 2017 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

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