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Archive

This is a library of Lhasa's blog articles. 

  • One of the most influential scientific papers blog2
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    One of the most influential scientific papers of 2022

    In November last year, we published a ground-breaking article to Chemical Research in Toxicology titled ‘What Makes a Potent Nitrosamine? Statistical Validation of Expert-Derived Structure–Activity Relationships’.  

    Within the paper, we show that certain structural features, when treated independently, have a statistically significant impact on the carcinogenic potency of nitrosamines. It is with great excitement that we share this publication making it to Chemical Research in Toxicology’s top 20 most downloaded articles, as well as being the most viewed article within their November edition. 

    26 January 2023

  • Complex nitrosamines blog
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    The benefits of joining the Complex Nitrosamines consortium

    Read what one of our Complex Nitrosamines Data Sharing Initiative members, Graham Smith, Oncology Chemical Toxicology Lead at AstraZeneca, has to say about being involved in this growing consortium!

    10 October 2022

  • Supporting N nitrosamine risk assessments for drug products
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    Supporting N-nitrosamine risk assessments for drug products

    N-Nitrosamine risk assessment and control have become an integral part of pharmaceutical drug product development. In this article, we discuss 3 key stages of risk assessment: identifying the source of risk, determining the level of activity and mitigating the risk. Discover how our in silico tools can be used to support informed decision making on chemical safety, in this blog article.

     

    25 July 2022

  • Replace reduce refine
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    Replace, Reduce, Refine - How Lhasa Limited are supporting the 3Rs

    Last year, a revolutionary guideline on Defined Approaches for Skin Sensitisation (OECD GL No.497) was released by the OECD. It is the first ever guideline that recommends the use of a combination of non-animal methods to predict whether a chemical can cause skin allergies. Since the publication of this guideline, Lhasa Limited have developed ‘Skin Sensitisation Defined Approach ITSv1 1.0’ – a web application containing one of the defined approaches published by the OECD, which provides hazard and potency skin sensitisation predictions without the use of animal tests. This tool is a step towards full replacement of animal testing for skin sensitisation and employs the 3Rs principle.

    02 March 2022

  • Predicting N-nitrosamine carcinogenic potency using structure-activity relationships (SARs)
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    Predicting N-nitrosamine carcinogenic potency using structure-activity relationships (SARs)

    This blog article introduces an insightful publication by Lhasa Principal Scientist, Dr. David Ponting and Dr. Kevin Cross from Instem, which investigates whether improvements in structure-activity relationships can more accurately predict N-nitrosamine carcinogenic potency.

    17 December 2021

  • How Derek Nexus and Sarah Nexus meet the 5 OECD principles
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    How Derek Nexus and Sarah Nexus meet the 5 OECD principles

    In this article, we discuss how Derek Nexus and Sarah Nexus meet the 5 OECD principles.

    30 November 2021

  • Derek Nexus Achieving high accuracy with high coverage
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    Derek Nexus – Achieving high accuracy with high coverage [an infographic]

    In this blog piece, we explore how Derek Nexus performs when evaluated against 7 different in silico skin sensitisation models.

    11 August 2021

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