Dr. Sébastien Guesné, Senior Scientist
Name: Dr. Sébastien Guesné
Job Title: Senior Scientist
My name is Sébastien and I graduated with a PhD in Organic and Synthetic Chemistry from the University of Exeter in 2005. I applied my laboratory and chemistry skills over 8 years on medicinal chemistry and pharmaceutical projects in Montreal, Canada, and London, United Kingdom, in research assistant positions.
I joined Lhasa Limited in 2013 as a scientist, where my early role was to use my experience in chemistry to derive knowledge from data and implement it into the Derek Nexus prediction software. I have been working on two challenging toxicological endpoints: skin sensitisation and hepatotoxicity. In 2015 I joined the Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI) consortium to provide cheminformatics’ solutions to the in silico hazard prediction of the hepatotoxicity endpoint from chemical structures in the Adverse Outcome Pathway (AOP) framework. In 2016 I took over as project leader of the long running collaborative project between Lhasa and the National Institute of Health Sciences (NIHS) of Japan. In the last two years these projects have focussed on implementing a hepatotoxicity profiler prototype and a visualisation tool.
Working for Lhasa Limited has given me the opportunity to work with inspirational people as well as providing me with scientific challenges to tackle. Notably, in February 2018, I moved into a Research Cheminformatician role as a secondee in the Molecular Informatics Team. In this role, I am responsible for the design and implementation of cheminformatics’ solutions in the area of applicability domain intended to support the development of new and existing predictive models.
Besides working at Lhasa Limited, if I am not with my family, you might find me hiking in the Yorkshire Dales.