Derek Nexus version 6.2.1 Skin sensitisation QMRF
Derek Nexus version 6.2.1 contains 133 alerts for skin sensitisation, together with reasoning rules encoding physicochemical descriptors. In addition to a prediction of skin sensitisation
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Derek Nexus version 6.2.1 Chromosome damage QMRF
Derek Nexus version 6.2.1 contains 105 alerts for chromosome damage, together with reasoning rules. These describe numerical (e.g. aneugenic) and structural (i.e. clastogenic) chromosomal aberrations
Sarah Nexus version 3.2.1 Mutagenicity QMRF
Sarah Nexus makes predictions for mutagenicity using fragment-based structural hypotheses derived from a statistically learned self-organising hypothesis network (SOHN) built using bacterial reverse mutation test
Derek Nexus version 6.2.1 HERG QMRF
Derek Nexus version 6.2.1 contains 5 alerts for HERG (human Ether-à-go-go-Related Gene) channel inhibition, together with reasoning rules encoding physicochemical descriptors. Find current QMRFs here,
Derek Nexus version 6.2.1 Mutagenicity QMRF
Derek Nexus version 6.2.1 contains 154 active alerts for bacterial mutagenicity, together with reasoning rules and secondary functionality that evaluates potentially misclassified and unclassified features
Derek Nexus version 6.2.1 Teratogenicity QMRF
Derek Nexus version 6.2.1 contains 51 alerts for Teratogenicity together with reasoning rules. Find current QMRFs here, for historical versions of Derek Nexus and Sarah
Derek Nexus version 6.2.1 Carcinogenicity QMRF
Derek Nexus version 6.2.1 contains 79 active alerts for carcinogenicity (both genotoxic and non-genotoxic), together with reasoning rules. Find current QMRFs here, for historical versions
Derek Nexus version 6.2 Chromosome damage QMRF
Derek Nexus version 6.2 contains 105 alerts for chromosome damage, together with reasoning rules. Find current QMRFs here, for historical versions of Derek Nexus and
Carcinogenicity assessment
Supporting accurate and cost-effective carcinogenicity risk assessment
How Derek Nexus and Sarah Nexus meet the 5 OECD principles
Are you aware of the 5 OECD principles, which validate (Q)SAR models for their use in regulatory assessment of chemical safety? The Joint Research Centre