Lhasa Limited is pleased to be contributing to the International Workshop on Genotoxicity Testing (IWGT) 2026, where our scientific experts will help shape discussions on the future role of in silico approaches in genetic toxicology.
Unlike a traditional scientific conference, IWGT brings together international experts in invitation-only working groups to address key scientific and regulatory challenges. These facilitated panel discussions are developed into consensus reports that have historically influenced genotoxicity testing strategies and regulatory guidance worldwide. Attendees are also welcome to observe the discussions from the floor, providing a unique opportunity to witness scientific consensus being built in real time.
Representing Lhasa at IWGT
Dr David Ponting will chair the session “Strengths and Limitations of In Silico / (Q)SAR Approaches”, with Dr Natan Segretti serving as a panel member alongside an international group of experts from industry, academia and regulatory organisations.
The panel will explore how in silico methodologies can support the next generation of regulatory decision-making, moving beyond their established role within ICH M7 to consider broader applications across genetic toxicology.
Discussions will focus on four key questions:
- Beyond M7: For which assays and use cases are we ready to replace experimental testing with in silico approaches, and how?
- Closing the gap: Where replacement is not yet possible, what are the scientific barriers and how can they be addressed?
- Setting a limit: What role should quantitative predictions and safety factors play in regulatory decision-making?
- Choosing your method: How do different in silico methodologies complement one another, and how should they be selected for different contexts?
The outcome of these discussions aims to provide a roadmap for improving confidence and regulatory acceptance of in silico methods, helping define where these approaches can responsibly reduce reliance on experimental testing while maintaining robust scientific standards.
As with previous IWGT workshops, the panel’s conclusions are expected to contribute towards future consensus publications that inform international regulatory practice.
We look forward to sharing key insights from the workshop following the event, including highlights from the panel discussions and their implications for the future of computational toxicology.