Meteor
Predictive metabolism & metabolite identification software. Predict metabolic fate with clarity, confidence and efficiency.
Introducing Meteor 4.0, the next generation of in silico metabolism prediction. Rebuilt and refined to help you predict, interpret, and justify the metabolic fate of chemical structures with an intuitive, evidence-driven workflow.
Speak with our team to learn how Meteor provides a clear, expert-led framework for efficiently identifying experimentally seen metabolites and understanding the biotransformation’s of your compound.
Confident metabolite identification
Quickly filter results by mass, phase, enzyme, biotransformation, or structural pattern to align with your mass spectrometry data.
Understand potential toxicity of metabolites
Seamless integration into Derek Nexus allows for easy assessment of toxicity endpoints.
Ensure compliance with ICH and REACH
Transparent reasoning, mechanistic evidence, and referenced biotransformation pathways.
Why choose Meteor for your metabolism predictions?
Meteor is a knowledge-based expert system, providing clear mechanistic rationales and literature-derived evidence for every prediction, giving you the transparency needed for internal decisions and regulatory justifications.
- Remove uncertainty when screening potential drug candidates.
- Understand all potential biotransformations and quickly identify experimentally observed metabolites.
- Support submissions under ICH M7, ICH M3 (MIST), ICHQ3A&B and REACH guidelines.
Understand your compounds metabolites for confident workflows and regulatory submissions.
Request a Meteor demonstration
Frequently asked questions
What is drug metabolism prediction software?
Drug metabolism prediction software is a computational tool used to predict how a drug candidate will be metabolised in the body. These tools identify potential metabolic pathways, likely metabolite structures, and enzymes involved in metabolism, helping researchers anticipate metabolic liabilities early in drug discovery.
How does Meteor predict metabolites?
How does Meteor support toxicology assessments?
Meteor integrates with Derek Nexus, enabling automatic evaluation of predicted metabolites for potential toxicological hazards, supporting early safety assessment.
How can software help identify drug metabolites?
Metabolism prediction software can generate likely metabolite structures based on known metabolic reactions and enzyme mechanisms. Researchers can compare predicted metabolites with experimental data from MS studies to accelerate the identification of experimentally observed metabolites.
Why is metabolite identification important in drug discovery?
Metabolite identification helps researchers understand how a compound is transformed in biological systems. Identifying metabolites allows scientists to evaluate drug efficacy, detect potentially toxic metabolites, and ensure compliance with regulatory guidelines for drug safety.
Can computational tools predict metabolite toxicity?
Yes. Metabolism solution Meteor integrates with the Derek Nexus solution for toxicity prediction capabilities that analyze metabolite structures for known toxicophores, reactive functional groups, or structural alerts. This allows researchers to assess potential safety risks before conducting expensive experimental studies.
How does metabolism prediction support metabolite safety assessment?
Predicting metabolites early in drug discovery helps researchers identify potentially problematic metabolites before clinical development. This enables scientists to modify chemical structures, design safer drug candidates, and reduce the likelihood of late-stage safety issues.
How are predicted metabolites validated experimentally?
Predicted metabolites are typically validated through analytical techniques such as mass spectrometry. Researchers compare predicted metabolite structures with experimental mass spectra to confirm metabolite identities.
How does metabolism prediction help reduce drug development risk?
By predicting metabolic pathways and potential toxic metabolites early, metabolism prediction tools help researchers identify metabolic liabilities before expensive preclinical or clinical studies. This supports safer compound design and more efficient drug development.
Can metabolism prediction software predict cytochrome P450 metabolism?
Yes. Meteor models reactions catalysed by cytochrome P450 enzymes (Using SmartCYP), which are responsible for a large proportion of drug metabolism. Predicting these reactions helps researchers identify likely metabolic hotspots and understand how compounds may be transformed in the liver.
What is phase I metabolism prediction?
Phase I metabolism prediction focuses on transformations such as oxidation, reduction, and hydrolysis that modify the structure of a compound. These reactions are commonly mediated by enzymes like cytochrome P450 and often generate metabolites that may undergo further processing.
What is phase II metabolism prediction?
Phase II metabolism prediction models conjugation reactions such as glucuronidation, sulfation, acetylation, or glutathione conjugation. These reactions generally increase the solubility of metabolites, helping the body eliminate them more efficiently.