In today’s chemical safety landscape, scientists need reliable data to make confident decisions. Challenges in toxicology risk assessments continue to evolve alongside the advancements seen across the regulatory landscape and the continuously developing methodologies that meet guidelines. Vitic is Lhasa Limited’s expertly curated toxicity database, developed to support informed decision-making in this ever-changing space.
In this blog, we’ll outline three problem-solving features of Vitic, reported by Toxicologists just like you, whilst also addressing how Vitic’s expert toxicity data can strengthen toxicology risk assessment workflows.
How to use Vitic in toxicology risk assessments?
Vitic is a high-quality toxicity database that enables structure-based searches and rapid access to expertly curated data. It offers full visibility of public and proprietary toxicity data in order to enhance decision-making. You can quickly identify relevant experimental data and assess its source before using the information to evaluate chemical safety hazards, specifically for mutagenicity and carcinogenicity.
Build comprehensive queries to search the database for information on compounds, as well as use it to solve three common problems.
Click below to discover the problem-solving capabilities of Vitic.
Vitic FAQs & Video Series
Efficient Toxicology Risk Assessments with Vitic: Searching Multiple Toxicity Data Sources
With a user-friendly query builder, you can search and identify the data you’re most interested in.
Watch the video below or view commonly asked questions regarding the efficiency of Vitic in specific sectors:
Why do toxicologists choose Vitic over public databases?
Vitic supports a range of safety assessments. It serves across multiple industries and provides expertly curated data from beyond public sources. This includes regulatory aligned and industry donated data.
For specific sectors, the datasets in Vitic are larger than those of public repositories:
- Pharmaceuticals – Supports in silico mutagenicity studies, carcinogenicity assessments, and evaluations of non-genotoxic impurities, including nitrosamines.
- Cosmetics – Assists with skin-sensitisation and irritation assessments, drawing on CIR and SCCS/SCCP data.
- Agrochemicals – Provides genotoxicity data and JMPR references to strengthen pesticide risk evaluations.
- Medical devices – Facilitates extractables and leachables work by supplying data on sensitisation, irritation, genotoxicity, and carcinogenicity.
Why choose Vitic over free databases?
Free datasets are likely to be curated by local governments or academic institutions, making them more suitable for preliminary and non-commercial research.Vitic offers a robust foundation for risk assessment decision-making, because its data quality is aligned with regulatory submissions.
Unlike free resources, Vitic datasets are expanded by industry data donations (from the top 20 in pharma) as well as accessed by regulatory bodies, as part of the Vitic data sharing initiatives. This helps you submit with confidence and ensures you work with in-depth, structured data which enables compliance and advances in research and development.
With over 30,000 peer-reviewed toxicity records, Vitic differs from free datasets by:
- Aligning with safety assessment requirements: Provides data on carcinogenicity, genotoxicity, and skin sensitisation, with over 22,000 substances. It also hosts peer-reviewed data to support ICH M7 submissions.
- Reliably updated by Data Sharing Consortiums: Facilitates industry collaboration on specific topics like aromatic amines, elemental impurities (ICH Q3D), complex nitrosamines and nitrite impurities.
Reliable Toxicology Risk Assessments with Vitic: Identify Relevant Data with Advanced Searches
With the ability to combine multiple substructure searches, you can automate the identification of any relevant toxicity data.
Watch the video below and uncover the answers to some commonly asked questions regarding the reliability of data housed in Vitic:
How often is Vitic updated?
Updates are made to the Vitic dataset annually, with the database and underlying software receiving updates as often as required to meet user demands.
Each year we release new data to the in silico tool, with the most recent release encompassing 10,814 total new data records and 139 new substances. Expansions of the database are populated and peer-reviewed by scientists at Lhasa Limited to ensure quality and confidence.
The continuous growth of Vitic is a result of data donations across regulatory and industry landscapes. For an extended period of time we collate, review and peer assess various data inputs, releasing all new records simultaneously in one release, which occurs at least annually.
Where does the data in Vitic come from?
Simply, historical in vivo experimental data from a variety of toxicological endpoints, including carcinogenicity, genotoxicity, and skin sensitisation. Sourced from regulators, publications, research and industry donations.
Lhasa also collaborates exclusively with industry experts through several Lhasa-derived data sharing initiatives. This enables us to gather high quality experimental data that is useful and valuable to various toxicology risk assessment workflows, including mutagenicity data, for example, which can be sought from our aromatic amines, excipients and complex nitrosamines data sharing initiatives.
Each data sharing group has a consortia, who is responsible for regular meetings to address the latest advancements and findings in their respective collaboration field. By sponsoring a data sharing initiative and Vitic, you can exchange further knowledge and shared data.
To ensure you can search through the highest quality of existing experimental data, each record is extracted manually by our scientists to maintain accuracy between Vitic data and the original data source, before being peer reviewed by a second member of the science team.
What extra functionality does Vitic offer?
Vitic is designed for flexibility. In order to offer the best support to your toxicology risk assessment workflow, here’s some additional features:
- Export data for further analysis or reporting
- Create custom datasets
- Work within a common data model, tailoring the platform to your specific workflows
Functionality like the above makes it easy to incorporate Vitic into broader R&D or regulatory strategies.
Being able to export data allows Lhasa to support toxicologists to conduct advanced and tailored analysis. Helping them to navigate Vitic data alongside their own tools, like Python. This is particularly useful for cross-study comparisons and improving data visualisation.
The toxicity database from Lhasa is also a single source of truth. Having a centralised system that all users rely on ensures the same accurate, validated, and up-to-date data is being used.
This is paramount with regulatory compliance, standardised data quality and reproducibility. Collectively, these functionalities enable the most confident decision to be reached.
Confident Toxicology Risk Assessments with Vitic: Robust Assessment of Internal & External Data
Showcasing internal toxicity datasets alongside public and proprietary records, allows you to confidently perform risk assessments using the most robust data.
Watch the video below and unlock the answers to common questions regarding Vitic’s integration opportunities:
Yes, it integrates directly with Derek Nexus and Sarah Nexus, allowing you to combine toxicity predictions with curated data and streamline cross‑checks during safety assessments.
This is a great example of an ICH M7 mutagenicity risk assessment involving (Q)SAR predictions.
Vitic is also the starting point of various other toxicology risk assessments. This means it can be used alongside many of our other in silico solutions to achieve a best practice workflow.
For example, Vitic integrates within a complete nitrosamine risk assessment. Here, it is featured alongside solutions such as Acrostic, LCDB Plus, Zeneth and more!
Simply put, integrating internal data alongside Vitic data will harmonise experimental results and ensure they are standardised in a way for best and most efficient interpretation.
The scientific rigor this adds to the data which is influencing decision making is invaluable.
Integrating custom data into a larger, curated dataset also enhances the accuracy of your toxicological risk assessment. For instance, data standardisation can impact onward (Q)SAR and read-across models.
Integrating internal data with Vitic data also aligns with moving away from a siloed in vivo approach, reducing traditional animal testing requirements and creating a more efficient, software-driven in vitro and computational approach.
Various global regulators have access to the Vitic database. This ensures Vitic toxicity data referenced in automated exports or custom reports for regulatory submissions can be simply validated and easily traceable.
Try Vitic for yourself, get in touch for a trial...
We hope you enjoyed our video series exploring the ways in which Vitic can facilitate efficient, reliable and confident toxicology risk assessments.
Complete the form to receive further information about Vitic and to book a demo. Unlock data-led decisions at your fingertips, in just a few clicks!
Related solutions...
Explore our other in silico solutions that can help you monitor the risk of formation, and toxicological concern of nitrosamine impurities: Mirabilis, Zeneth, Derek Nexus, Sarah Nexus, Vitic, and the Lhasa Carcinogenicity Database.
Last Updated on March 5, 2026 by lhasalimited
