Lhasa Limited is pleased to announce the launch of the latest version of Acrostic, a significant update to its powerful read-across solution for assessing untested nitrosamine carcinogenicity. The expert-led framework supports teams to confidently assign acceptable intake (AI) limits with a clear and defensible scientific rationale when building assessments aligned with regulatory guidance.
This version builds upon the scientifically robust foundation of Acrostic. The main driver for the update was to enable enhanced decision-making with a more transparent and efficient user experience, automating industry-wide best practice. The updated workflow better supports:
- Quick review of potential surrogates with clear scientific context, expert reasoning and confidence scores – giving users more time for expert interpretation.
- Confidently base your assessment on the latest nitrosamine science with automated access to up-to-date, public and proprietary datasets to facilitate decision making.
- Comprehensively document your entire assessment in a single report, providing a transparent evidence package to support your target compound conclusion.
This expert-led framework transforms the assessment into a manageable and logical process, giving the user complete ownership of their final scientific position.
Agnieszka Ceszlak, Associate Director within Science at Lhasa, outlines the value the updated process in Acrostic will deliver:
“Acrostic was developed to support decision making when defining AI limits for novel, untested nitrosamines, using a read-across approach.
The goal of this Acrostic update is clear: to bring exceptional clarity to a complex workflow. We provide scientists with a more streamlined and robust way to approach their assessments by structuring the necessary data, automating critical checks and transparently documenting the process. This allows experts to focus their time on the final scientific judgement, armed with confidence in the underlying evidence.”
Dr Adrian Fowkes, Director of Science at Lhasa, added:
“A key challenge facing wide acceptance of read-across is the varied approaches taken by experts. Acrostic addresses this directly. We focused on standardising the workflow to produce consistent and robust decisions which are based on extensive expert knowledge and data embedded into the tool. Acrostic helps assessors make confident decisions more quickly.”
For more information on the software, visit the Acrostic assessment page.
Interested in a free demonstration to see the updated version of Acrostic in action? Get in touch with a Lhasa scientist here.