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Lhasa Limited is a not-for-profit organisation and educational charity that facilitates collaborative data sharing projects in the pharmaceutical, cosmetics and chemistry-related industries.
Membership
Lhasa Limited is a Membership Organisation Details of membership options and member roles can be seen on this page.
Benefits of Membership
The Needs of our Users At Lhasa Limited we ...
ICGM
What is an ICGM? ICGMs (International Collaborative Group Meetings) ...
Become a member
Details of how to find out about becoming a member of Lhasa Limited.
Current members
A list of current Lhasa Limited membership organisations.
Products
Details of Lhasa Limited's product portfolio.
Derek Nexus
Derek Nexus is the expert, knowledge-based software that gives you accurate toxicity predictions quickly. Early, accurate in silico toxicity tests using Derek Nexus is the quick, inexpensive way to identify potentially toxic chemicals, aiding your experts in rejecting unsuitable drug candidates.
Negative Predictions for Bacterial Mutagenicity
Derek Nexus contains expert-derived functionality to provide negative predictions for bacterial in vitro mutagenicity.
EC3 Predictions For Skin Sensitisation
A description of the EC3 prediction function within Derek for skin sensitisation. Detailing the methodology, performance, features and benefits.
Derek Knowledge Editor and Web Services
A page detailing Derek Knowledge Editor and Web Services
Derek Features and Benefits
A list of the key features and benefits of Derek Nexus
Member Only Content
Landing page for access to Derek Nexus member only content.
What's New?
An overview of the new software features and knowledge elements in Derek Nexus
Downloads & IT Support
Access the latest download (software recipients only), find out about known issues, patches, fixes and FAQs, and understand why something is not predicting in Derek Nexus.
Training & Events
 
Meteor Nexus
Expert, knowledge-based software for predicting metabolic fate
Meteor Reasoning Methodologies
A description of the three methodologies in Meteor Nexus: Absolute/Relative Reasoning, Static Scoring (Occurrence Ratio) and Site of Metabolism (SOM) Scoring.
Meteor Features and Benefits
A list of the key features and benefits of Meteor nexus.
Member Only Content
Landing page for access to Meteor Nexus member only content.
What's New?
An overview of the new software features and knowledge elements in Meteor Nexus
Downloads & IT Support
Access the latest download (software recipients only), find out about known issues, patches, fixes and FAQs.
Training & Events
Virtual ...
Sarah Nexus
Sarah Nexus is a statistical software tool that gives you accurate mutagenicity predictions quickly.
Sarah Nexus Model Building
Sarah Nexus is a statistical software for the prediction of mutagenicity. This page describes how to use the Sarah model building functionality.
Sarah Nexus Features and Benefits
Sarah Nexus is a statistical software for the prediction of mutagenicity. This page details the features and benefits of Sarah Nexus
Member Only Content
 
What's New?
Find out more about new and future developments in Sarah Nexus, as well as relevant news articles.
Downloads & IT Support
Access the latest download (software recipients only), find out about known issues, patches, fixes and FAQs.
Training & Events
Virtual ...
Sarah FAQs
A list of frequently asked questions about Sarah Nexus.
Mirabilis
Mirabilis is an industry-standardised approach providing an expert and scientifically robust software for the calculation of purge factors of potentially mutagenic impurities in a synthetic route.
Mirabilis Features and Benefits
Mirabilis is an expert and scientifically robust software for the calculation of purge factors. This page details the features and benefits of Mirabilis.
Member Only Content
 
What's New?
 
Mirabilis Fixes, Known Issues & Patches
 
Vitic Nexus
Vitic Nexus is the next generation chemical database and information management system, offering researchers and scientists rapid access to searchable toxicological information. Early review of Vitic Nexus is the quick, inexpensive way to identify potentially toxic chemicals, and therefore reject unsuitable drug candidates. Vitic Nexus is your trusted toxicity expert and management system; containing data implemented by scientists at Lhasa Limited, who continually work on the toxicity database with current toxicological knowledge.
Vitic Features and Benefits
This page details the features and benefits of using Vitic Nexus
Member Only Content
Landing page for access to Vitic Nexus member only content.
What's New?
An overview of the new software features and data elements in Vitic Nexus
Downloads & IT Support
Access the latest download (software recipients only), find out about known issues, patches, fixes and FAQs.
Training & Events
Virtual ...
Zeneth
Zeneth is an expert, knowledge-based software that gives you accurate forced degradation predictions quickly. Zeneth is the perfect cost-effective solution for scientists who need to understand the forced degradation pathways of organic compounds. Zeneth is your trusted degradation expert system. It is based on data implemented by scientists at Lhasa Limited, who continually work on the transformation knowledge base with current transformation knowledge.
Zeneth Features and Benefits
This page details the features and benefits of Zeneth.
Member Only Content
Landing page for access to Zeneth member only content.
What's New?
An overview of the new software features and knowledge elements in Zeneth
Downloads & IT Support
Access the latest download (software recipients only), find out about known issues, patches, fixes and FAQs.
Training & Events
Virtual ...
Nexus
An overview of Nexus, the hub of the Lhasa Knowledge Suite
Member Only Content
 
What's New?
At Lhasa Limited, we are always striving to make ...
Known Issues
 
Nexus FAQs
FAQ ...
ICH M7
ICH M7 provides a practical framework for the identification, categorization, qualification and control of mutagenic impurities to limit potential carcinogenic risk. Lhasa Limited can support you through implementation of these guidelines.
ICH M7 Features and Benefits
Lhasa Limited can help you to organise the relevant information for an ICH M7 submission. Using the ICH M7 functionality within the Nexus Suite, Derek and Sarah Nexus are brought together to provide the expert rule-based and statistical-based in silico predictions required under ICH M7. By additionally providing the Nexus Suite with information about the API, an ICH M7 calculation can be made which can take into account in-house or Vitic Nexus data.
ICH M7 Expert Review
Expert assessment is a fundamental part of the assessment of the mutagenic potential of impurities under the ICH M7 guideline and it makes a specific provision for the application of expert knowledge to support or overturn a (Q)SAR prediction. Whilst expert assessment has been successfully applied in this context, the definition of what constitutes expert analysis has been largely left open. Chris Barber et al. have recently outlined their views on establishing best practice in the application of expert review under ICH M7.
3-fluoro-4-phenylaniline - Positive - Positive
Worked Example for ICH M7 submission using Derek and Sarah, plus an expert review.
Phenyltrifluoroborate - Positive - Out of Domain
Worked Example for ICH M7, using phenyltrifluoroborate. This shows a prediction for Derek and Sarah Nexus and included expert review.
N-Propyl Triazoline - Positive - Negative
Worked example for ICH M7 submission using N-Propyl Triazoline. Includes a prediction from Derek and Sarah Nexus plus expert review.
Methyl Sulfate - Negative- Equivocal
A worked example of Methyl Sulfate for an ICH M7 submission. This includes a prediction from both Derek and Sarah Nexus, and an expert review.
Tolfenamic acid - Negative - Negative
A worked example of Tolfenamic acid for an ICH M7 submission. This includes a prediction from both Derek and Sarah Nexus, and an expert review.
FAQs
This FAQs section details frequently asked questions about the ICH M7 guidelines. For FAQs on Lhasa products, please refer to the relevant product area.
Training & Technical Support
Lhasa Software ...
Setaria
A workflow tool designed to store and track internal and external data and ensure ICH mM7 compliance.
Library
The Library provides access to various documents, including publications, papers, posters and presentations.
Search the Library
 
Publishing about Lhasa?
A toolkit to assist authors when publishing about Lhasa Limited or it's products.
Initiatives
Details of current and recent collaborations with Lhasa Limited involvement
AI/PDE
A data sharing initiative to share Acceptable Intake (AI) and Permitted Daily Exposure (PDE) data.
Aromatic Amines
The Aromatic Amines project aims to improve the understanding and predictability of the Ames test outcome for primary aromatic amines. This project is one of several projects initiated by Lhasa Limited that enables pre-competitive data sharing.
Elemental Impurities
The Elemental Impurities project is a new, collaborative data-sharing project; one of several projects initiated by the pharmaceutical industry, in partnership with Lhasa Limited, which enables pre-competitive data sharing.
Elemental Impurities FAQs
FAQ ...
eTOXsys
This page gives a summary of eTOXsys and directs to the eTOXsys website.
EU-ToxRisk
This page contains information on the EU-ToxRisk project, an Integrated European ‘Flagship’ Programme Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st century.
Excipients
Vitic Excipients is a pre-competitive data sharing project that enables collaborative sharing of vehicle toxicity data from company archives.
FDA RCA
The FDA RCA (Research Collaboration Agreement) is a 5-year project between Lhasa and CDER FDA from 2012 to 2017. The RCA is the result of a continuing collaboration and started after closure of the previous 5-year FDA CRADA project. The aim is to use FDA datasets towards improving Lhasa existing products (e.g. Derek Nexus) and ongoing research activities. Since March 2015, the work carried out under this collaboration also includes exploitation of in vitro and other relevant data in addition to in vivo DART information towards the prediction of molecular initiating events relevant to teratogenicity, an initiative to offer predictions over a significantly wider chemical space and which gathered considerable interest from industry experts.
iPiE
The iPiE project is a 4 year project funded by the Innovative Medicines Initiative Joint Undertaking. The aim is to develop frameworks to support the environmental testing of new pharmaceuticals and to help prioritise testing of legacy APIs.
Lhasa Carcinogenicity Database
The Lhasa Carcinogenicity Database has been founded on the Carcinogenic Potency Database (CPDB), a widely used, free resource which contains the results of animal cancer tests. Lhasa Limited has used its knowledge in the field of user experience to add new functionality, building on the excellent work of the team behind the original database.
Production Intermediates
Vitic Intermediates is a pre-competitive data sharing project that enables collaborative sharing of Ames mutagenicity data for production intermediates.
News
News View historic ...
Events
Calendar ...
Sitemap
Site ...
About Us
A general overview of Lhasa Limited.
Careers
Content page holding all current job advertisements for Lhasa Limited.
Charitable statement
Lhasa Limited is committed to the development and use of computer-aided reasoning and information systems for the advancement of chemistry and the life sciences. By performing research on chemical, toxicology and metabolism data, our scientists are able to provide members with software systems that allow them to make predictions about the safety of chemicals.
Staff Profiles
The biographies of various members of staff at Lhasa Limited, in particular those in customer-facing roles or actively engaging with members.
Dave Watson, CEO
Profile for Lhasa Limited CEO, Dave Watson.
Dr. Chris Barber, CEO
Profile for Lhasa Limited Chief Executive Officer, Chris Barber
Jonathan Vessey, Research Leader
Profile for Lhasa Limited Research Leader, Jonathan Vessey
Edward Rosser, Research Cheminformatician
Profile for Lhasa Limited Research Cheminformatician, Ed Rosser
Dr. Steven Canipa, Research Cheminformatician
Profile for Lhasa Limited Research Cheminformatician, Steven Canipa
Dr. Richard Williams, Principal Scientist
Profile for Lhasa Limited Principal Scientist, Richard Williams
Mukesh Patel, Principal Scientist
Profile for Lhasa Limited Principal Scientist, Mukesh Patel
Dr. Martin Payne, Senior Scientist
Profile for Lhasa Limited Senior Scientist, Martin Payne
Dr. David Ponting, Senior Scientist
Profile for Lhasa Limited, David Ponting, Senior Scientist
Dr. Ash Ali, Senior Scientist
Profile for Lhasa Limited Senior Scientist, Ash Ali.
Dr. Lilia Fisk, Senior Scientist
Profile for Lhasa Limited Senior Scientist, Lilia Fisk
Dr. Sebastien Guesne, Scientist
Profile for Lhasa Limited Scientist, Sebastien Guesne
Laura Gibson, Principal Scientist
Profile for Laura Gibson, Lhasa Limited, Principal Scientist
Dr. Alun Myden, Scientist
Profile for Lhasa Limited Scientist, Alun Myden
Dr. Tony Long, Principal Scientist
Profile for Lhasa Limited Principal Scientist, Tony Long
Dr. Ernest Murray, Senior Scientist
Profile for Lhasa Limited, Principal Scientist, Ernest Murray
Dr. Andrea Sartini, Scientist
Profile for Lhasa Limited Scientist, Andrea Sartini
Dr. Steven Kane, Scientist
Profile for Lhasa Limited, Steven Kane, Scientist
Dr Susanne Stalford, Senior Scientist
Profile for Lhasa Limited, Senior Scientist, Susanne Stalford
Dr. Lara James, Scientist
Profile for Lhasa Limited, Dr. Lara James, Scientist
Dr Natasha Murphy, Scientist
Profile for Lhasa Limited, Natasha Murphy, Scientist
Catherine O'Leary-Steele, Scientist
Profile for Catherine O'Leary-Steele, Scientist at Lhasa Limited.
Rosemary Porter, Pharmacokinetics Research Assistant
Profile for Rosemary Porter, Pharmacokinetics Research Assistant at Lhasa Limited
Martin Ott, Principal Scientist
Profile for Lhasa Limited Principal Scientist, Martin Ott
Dr. Rachel Hemingway, Scientist
Profile for Lhasa Limited Scientist, Rachel Hemingway
Dr. Alex Cayley, Senior Scientist
Profile for Lhasa Limited, Dr. Alex Cayley, Senior Scientist
Dr. Adrian Fowkes, Scientist
Profile for Lhasa Limited Scientist, Adrian Fowkes
Dr. Donna Macmillan, Senior Scientist
Profile for Lhasa Limited, Donna Macmillan, Senior Scientist, Knowledge Team
Dr. Martyn Chilton, Scientist
Profile for Lhasa Limited Scientist, Martyn Chilton
Mark Pinches, Senior Principal Scientist
Profile for Lhasa Limited, Mark Pinches, Senior Principal Scientist
Nazanin Golbamaki, Senior Research Scientist
Staff profile for Nazanin Golbamaki, Senior Scientist at Lhasa Limited
Lucinda Camidge, Pharmacokinetics Research Assistant
Profile for Lucinda Camidge, Pharmacokinetics Research Assistant , Lhasa Limited.
Katharine Briggs, Research Leader
Profile for Lhasa Limited Research Leader, Katharine Briggs
Andrew Thresher, Senior Scientist
Profile for Lhasa Limited Senior Scientist, Andrew Thresher
Anne-Laure Werner, Scientist
Profile for Lhasa Limited Scientist, Anne-Laure Werner
Grace Kocks, Scientist
Profile for Lhasa Limited Scientist, Grace Kocks
Emma Hill, Scientist
Profile for Lhasa Limited Scientist, Emma Hill
David Wilkinson, Senior Scientist
Profile for Lhasa Limited Senior Scientist, David Wilkinson
Reza Zarei, Scientist
Profile for Lhasa Limited Scientist, Reza Zarei
Robert Davies, Scientist
Profile for Lhasa Limited, Robert Davies, Scientist
John Lettice, Software Development Manager
Staff Profile for John Lettice for Lhasa Limited: Software Development Manager
Andrzej Paetz, Senior Software Developer
Profile for Lhasa Limited Senior Software Developer, Andrzej Paetz
Jakub Olszak, Software Developer
Profile for Lhasa Limited Software Developer, Jakub Olszak.
David Scott, Senior Software Developer
Profile for Lhasa Limited, Senior Software Developer, David Scott
Piotr Gorny, Analyst Developer
Profile for Lhasa Limited, Piotr Górny, Analyst Developer
Jing Ma, Senior Software Developer
Profile for Lhasa Limited Senior Software Developer, Jing Ma
Paul Cooke, Analyst Developer
Profile for Lhasa Limited Analyst Developer, Paul Cooke
Alan Hayward, Junior Software Developer
Profile for Lhasa Limited, Alan Hayward, Junior Software Developer
Dan Newman, Software Developer
Profile for Lhasa Limited Software Developer, Dan Newman
Dr Timothy Furze, Software Developer
Profile for Lhasa Limited, Software Developer, Dr Timothy Furze
Thomas Ball, Graduate Software Developer
Staff Profile for Thomas Ball, Graduate Software Developer at Lhasa Limited
Paul Cunningham, Test Analyst
Profile for Lhasa Limited Test Analyst, Paul Cunningham
Dr Jamie Atkins, Senior Test Analyst
Profile for Lhasa Limited, Senior Test Analyst, Jamie Atkins
Richard Titley-Sage, Graduate Test Analyst
 
James Brundell, Graduate Test Analyst
Profile for James Brundell, Graduate Test Analyst, Lhasa Limited.
Mohammad Anoshehpour, Software Developer
Staff profile for Mohammad Anoshehpour, Software Developer at Lhasa Limited.
Dr. Geraldine Poignant, Business Improvement Manager
Profile for Lhasa Limited, Geraldine Poignant, Business Improvement Manager
Lisa Wincup, Senior Technical Author
Lisa Whincup, Profile for Lhasa Limited
Mohsen Dehkordy, IT Manager
Profile for Lhasa Limited, Mohsen Dekordy, IT Manager
Thomas Greensmith, System Administrator
Profile for Lhasa Limited, Thomas Greensmith, system Administrator
Jennifer Horsley, Financial Controller
Profile for Lhasa Limited, director of finance, Jennifer Horsley
Michelle Gosling, Corporate Accountant
Profile for Lhasa Limited, Corporate Accountant, Michelle Gosling
Dr. Liz Covey-Crump, Director of Business Development
Profile for Lhasa Limited, Director of Business Development, Liz Covey-Crump,
Dr. Crina Heghes, Business Development Manager
Profile for Lhasa Limited Business Development Manager Crina Heghes.
Laura Johnston, Business Development Manager
Profile for Lhasa Limited Business Development Manager, Laura Johnston.
Dr. William Drewe, Business Development Manager
Profile for Lhasa Limited Business Development Manager, William Drewe
Nik Marchetti, Product Manager
Profile for Lhasa Limited Product Manager, Nik Marchetti
Lisa Leivers, Business Analyst
Profile for Lhasa Limited Business Analyst, Lisa Leivers
Simon Gayton, Business Analyst
Profile for Lhasa Limited Business Analyst, Simon Gayton
Diane Bureau, Web Application Designer
Profile for Lhasa Limited, Diane Bureau, Web Application Designer
Suzi Lomax, Senior Project Manager
Profile for Lhasa Limited Senior Project Manager, Suzi Lomax
Richard Bailey, Project Manager
Staff profile for Richard Bailey, Project Manager at Lhasa Limited
Clare Arnold, Project Manager
Profile for Lhasa Limited Project Manager, Clare Arnold
Kelly Gallagher
Profile for Lhasa Limited HR Adviser, Kelly Gallagher
Jo Raper, HR Administrator
Profile for Lhasa Limited, HR Administrator, Jo Raper
Anna Cameron, HR Administrator
Profile for Anna Cameron, HR Administrator at Lhasa Limited.
Get to know Chris Barber
Find out more about how Chris got here, his future plans, and what advice he has for aspiring scientists.
Dr. James Willans, CTO
Profile for Lhasa Limited CTO, James Willans.
Thierry Hanser, Research Leader
Staff profile of Thierry Hanser, Lhasa Limited.
Jean-Francois Marchaland, Research Software Development
Profile for Lhasa Limited, Research Software Developer, Jean-Francois Marchaland
Dr. Jeffrey Plante, Research Scientist
Profile for Lhasa Limited Research Scientist, Jeffrey Plante
Ruud Van Deursen, Research Cheminformatician
Profile for Ruud Van Deursen, Research Cheminformatician at Lhasa Limited
SAB Member - DG
 
SAB Member - AB
 
Board Member - KD
Profile for Krista Dobo, Board Member for Lhasa Limited
Contact Us
Details on how to contact Lhasa Limited and how to find us if you are visiting.
Leeds Office
Lhasa Limited's Head Office is based in Leeds: ...
Newcastle Office
Information about and directions to Lhasa's Newcastle Office.
Poznan Office
Information and directions for the Lhasa Limited Poznan Office, in English and Polish.
Enquiries in Brazil
 
Enquiries in China, Japan or Korea
Enquiries in ...
Info Request
Form to request product information from the sales team at Lhasa Limited
Support Request
Form to contact the Lhasa Limited Support Team with any queries relating to use or installation of the software.
Training Request
Form for requesting software training from Lhasa Limited
Call-back Request
Contact ...
Hotels and Parking
An overview of hotels and parking for visitors to Lhasa Limited.
Careers- Register your interest
A form to register your interest in possible future vacancies at Lhasa Limited.
Cookie Policy
We do not make use of cookies to collect ...
Download Centre
 
Members
Create a support ticket Create a data submission Request ...

© 2017 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

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