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Utilisation of Non-adverse Data to Predict Molecular Initiating Events and Teratogenicity for a Broader Chemical Space

pdf fileMyden A; Fowkes A; Hill E; Plante J; Surfraz B;

The scarcity of teratogenicity data and the cost of in vivo reproductive toxicity studies are driving the use of a wider range of assays, where the relationship between data and teratogenicity can be established. Similarly, this lack of data is affecting the reliability domain of prediction systems for teratogenicity. Using an adverse outcome pathway (AOP)framework, key events (KE) leading to teratogenicity can be mapped and suitable in vitro and in vivo assays, which model the KEs, can be identified. This type of relevant data is available for a significantly larger number of chemicals in comparison to teratogenicity data, which in turn can be mined to extract useful knowledge allowing for teratogenicity predictions for a broader chemical space.



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