Lhasa Limited shared knowledge shared progress
Publications

Strengthening the Case for in silico GTI Assessments.pdf

pdf fileBarber CG; Coquin L; Hanser T; Judson PN; Stalford SA; Vessey J; Williams RV;

In silico systems, such as structural alerts, are increasingly being used for the assessment of mutagenicity. Regulatory acceptance of such systems has recently been strengthened by a draft of the ICH M7 guidelines, which supports the use two complementary (Q)SAR prediction systems for assessment of genotoxic impurities (GTIs), one of which should be expert rule-based, and a second, statistically-based system. The basis of this acceptance is that predictive systems can rule out the possibility of mutagenic potential in GTIs. In this work, we have devised and tested a number of methods to enhance Derek Nexus alerts.

Presented by Susanne Stalford at SOT, San Antonio, USA; 10th - 14th March 2013.

Download

© 2019 Lhasa Limited | Registered office: Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK Tel: +44 (0)113 394 6020
VAT number 396 8737 77 | Lhasa Limited is registered as a charity (290866)| Company Registration Number 01765239 (England and Wales).

Thanks to QuestionPro's generosity, we now have survey software that powers our data intelligence.