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Redox cycling versus general liver toxicity: Read-across case study with phenols

pdf fileEscher S; Tluczkiewicz I; van de Burg B; van de Water B; Ouedraogo G; Maclennan R; Drewe WC; Beltman J; Grapel R; Bischoff L; Jennings P; Stober R; Hengstler J; Taboureau O; Aguayo A; Long A; Jain S; Ecker G; Mombelli E; Zgheib E; Bois F; Tolosa L; Hatley O; Pawar G; Norinder U; Abdelaziz A; Exner T; Zdrazil B;

In this case study, the aim is to develop non-animal methods (NAMs), which can be used to reduce the uncertainty of read across predictions. 19 phenols were selected based on their in vivo effects after repeated exposure and structural properties. In vivo, these alkylated phenols show apical findings like hypertrophy and weight changes indicating a non-specific general liver toxicity.

This case study explores to which extent the prediction of a specific or non-specific MoA is possible by NAMs developed within EU-ToxRisk.

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