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Mutagenicity Prediction Using In Silico Methods: Gigabyte-Sized Petri Dishes

pdf fileSanchez-Ruiz A;

This presentation was given by Antonio Sanchez-Ruiz at the 2016 XXII Congress of the Spanish Environmental Mutagenesis Society.


The use of predictive toxicology methodologies is advantageous for the following reasons: it reduces the use of animal tests and provides results in a faster way. Among the techniques employed, in silico toxicology has experienced a notable surge in interest, primarily because the increase in computational power has allowed the use of datasets and algorithms capable of yielding predictions as valid as a traditional in vitro assay. In this lecture, an overview of the predictive toxicology methods will be given, comparing in vitro and in silico approaches and showing how they fit within ICH M7 regulatory guidelines1. Special emphasis will be placed on in silico methods and how Lhasa solutions2,3 can be used to predict mutagenicity within this framework.


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