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Excipients data sharing initiative a step towards 3-R principle implementation.pdf

pdf fileKister M; Werner AL; Wilkinson D;

The Excipients Data Sharing Initiative is gathering proprietary and literature data in a central repository under a searchable format. Currently involving 11 pharmaceutical companies, the Excipients Database was first released in 2008 and its coverage in terms of vehicles, dosages, routes of administration, animal models and endpoints is continuously expanding. After giving an overview of the type of information within the database, a user case of its potential during early stages of new drug development is presented. Emphasis is placed on how such in silico tool addresses REACH requirements by encouraging data sharing between companies thus reducing unnecessary animal testing.

Presented by Anne-Laure Werner at 2nd International Summit on Toxicology, Las Vegas, USA; 7th - 9th October 2013.

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