Data Collection on Pharmacokinetic Parameters of Chemicals in the EUToxRisk Project
Presented by Tony Long at the 2019 EU-ToxRisk General Assembly and Open Symposium.
Absorption, distribution, metabolism, and excretion (ADME) are biological processes that determine the concentrations of a chemical in the body. Physiologically Based Pharmacokinetics (PBPK)
models are mathematical representations of these processes and provide estimations of the time-dependent chemical disposition. As part of the EU-ToxRisk work package 4 activities, Lhasa Limited have created a PBPK dataset that includes a list of chemical-specific parameters relevant in parameterising PBPK models. This poster aims to present the research performed on two main areas of the data collection activities:
- identification of sources of compound-specific PBPK data,
- number of data points gathered and prioritised sources based on the standard guidelines for the data quality