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    Springer
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    Methods for Stability Testing of Pharmaceuticals. Editors: Sanjay Bajaj, Saranjit Singh. ISBN 978-1-4939-7686-7
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Chapter 17: In Silico Drug Degradation Prediciton

Ali MA; Hemingway R; Ott MA;

Chapter 17 in Methods for Stability Testing of Pharmaceuticals: Sanjay Bajaj and Saranjit Singh

"This detailed volume collects numerous methods and protocols related to different aspects of stability programs that are followed in pharmaceutical development laboratories. Implementation of a successful stability program, vital in preventing product failures and recalls, requires critical and logical thinking that goes beyond the regular documented protocols and methods, so the experiences of the book’s internationally-based expert contributors fill the chapters with practical guidance.

As a volume in the Methods in Pharmacology and Toxicology series, this book presents the kind of real-world advice that is essential for advancing laboratory research.

Authoritative and thorough, Methods for Stability Testing of Pharmaceuticals serves as a valuable addition to the existing armamentarium of resources available to stability testing personnel in research and industry."

Chapter 17: In Silico Drug Degradation Prediction

Zeneth is an in silico tool that can provide insight into the chemical degradation of organic compounds under various environmental conditions. The program is therefore primarily employed within the pharmaceutical industry to understand and account for any potential degradation problems during API development. The program uses a knowledge base of chemical transformations together with a reasoning engine to determine the likelihood of a particular degradant. The knowledge base is continuously expanding and contains a diverse range of chemistries for many common functional groups.

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