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Analysis of human and in vivo data for hepatotoxicity modelling.pdf

pdf fileBriggs K; Patel ML;

The complexity of mechanistic causes of toxicity observed in in vitro or in vivo assays presents a challenge for the development of in silico prediction methodologies. We analysed a repeat dose dataset from the eTOX project to ascertain if relationships between reported histopathology or clinical chemistry could be elucidated, and if they extrapolated to reported human DILI.

Presented by Mukesh Patel at SOT, San Diego, USA; 22nd - 26th March 2015.


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