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An adverse outcome pathway framework to support developmental and reproductive toxicity risk assessments

pdf fileMyden A; Hill E; Fowkes A;

Traditional developmental and reproductive toxicity (DART) safety assessments are costly and time-consuming, due to the large numbers of animals involved. Alternative approaches to such assessments are receiving much attention, with the aim to improve efficiency and increase the human relevance of DART safety assessments. Adverse outcome pathways (AOPs) are able to store relevant knowledge to ground alternative mechanistic approaches and provide context of their results to risk assessors. Utilising AOPs in larger ontologies, where assays and in silico models are mapped to key events in an AOP network, will support the development of integrated approaches to testing and assessment for DART endpoints. Importantly, organising knowledge and data in this way, will provide confidence for risk assessors to progress with risk assessments


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