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Sarah NexusSarah Nexus Publications

The following links provide access to relevant Sarah Nexus publications for the last 2 years. If you would like to view older publications, or to refine your search criteria further please search the library.

TitlePublishedTypeProducts
Predictive Toxicology: Using In Silico SystemsOctober 2019pdf fileDerek NexusSarah Nexus
ICH M7 - Risk assessment for mutagenic impurities and control strategiesSeptember 2019Derek NexusMirabilisSarah Nexus
Toxicity Evaluation of Degradation ProductsJuly 2019pdf fileDerek NexusSarah NexusZeneth
(Q)SAR Evaluation of Drug Impurities from the US FDA Scientific PerspectiveJuly 2019pdf fileDerek NexusSarah Nexus
Managing Mutagenic Impurity Risks in Pharmaceutical ProductsJuly 2019pdf fileDerek NexusSarah Nexus
In silico prediction of MutagenicityJune 2019pdf fileSarah NexusDerek Nexus
Use of In Silico Tools for Toxicity Prediction Within ICH M7June 2019pdf fileDerek NexusSarah NexusVitic Nexus
RDC53: Challenges on impurities qualificationJune 2019pdf fileDerek NexusSarah NexusVitic NexusZeneth
Introduction to Lhasa - Applying ICH M7 - What makes an expertMay 2019pdf fileDerek NexusMirabilisSarah NexusMeteor NexusVitic Nexus
Modelling Simple Toxicity Endpoints: Alerts, (Q)SARs and BeyondMay 2019Derek NexusMeteor NexusSarah NexusVitic Nexus
A Suggested ICH M7 Framework Using Lhasa Limited ProductsMay 2019pdf fileZenethVitic NexusMirabilisSarah NexusDerek Nexus
A Case Study in Predicting hERG Activity.April 2019Derek NexusSarah NexusMirabilisMeteor NexusVitic NexusZenethSetaria
Improving In Silico Predictions in Developmental and Reproductive ToxicologyApril 2019Derek NexusSarah Nexus
ICH M7 Perception: Unifying Knowledge from Predictions to PurgingMarch 2019pdf fileMirabilisSetariaDerek NexusSarah NexusVitic Nexus
Product Update ICGM PresentationMarch 2019pdf fileDerek NexusSarah Nexus
Avoiding hERG-liability in drug design via synergetic combinations of different (Q)SAR methodologies and data sources: a case study in an industrial settingFebruary 2019Sarah NexusDerek Nexus
Advance your knowledge of ICH M7 A virtual expert review workshopFebruary 2019Derek NexusSarah Nexus
Save Time and Money with Lhasa LimitedDecember 2018pdf fileDerek NexusSarah NexusZeneth
Welcome and Introduction to ICH M7 - ICH M7 India RoadshowsNovember 2018pdf fileDerek NexusSarah NexusVitic Nexus
Sarah Nexus: The Statistical System for ICH M7 - ICH M7 India RoadshowsNovember 2018pdf fileSarah Nexus
Derek Nexus, Sarah Nexus and Vitic: How they fit into ICH M7 - ICH M7 India RoadshowsNovember 2018pdf fileDerek NexusSarah NexusVitic Nexus
An adverse outcome pathway framework to support developmental and reproductive toxicity risk assessmentsNovember 2018pdf fileDerek NexusSarah NexusVitic Nexus
Important considerations for the validation of QSAR models for in vitro mutagenicityNovember 2018Derek NexusSarah NexusVitic Nexus
Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge ProjectOctober 2018Derek NexusSarah Nexus
In Silico Predictions For GenotoxicityOctober 2018pdf fileDerek NexusSarah Nexus
Interpreting the Sensitivity and Equivocal Settings in Sarah NexusOctober 2018pdf fileSarah Nexus
Meeting report, ICH M7 relevant workshop: use of (Q)SAR systems and expert judgmentSeptember 2018pdf fileDerek NexusSarah Nexus
Development Of A Network Of Adverse Outcome Pathways (AOPs) For CarcinogenicitySeptember 2018pdf fileVitic NexusDerek NexusSarah Nexus
Mutagenicity Predictions using a Statistical SystemJune 2018pdf fileSarah Nexus
Toxicity Studies for Degradation Impurities - An Industry PerspectiveJune 2018pdf fileDerek NexusSarah Nexus
ICH M7 Use CasesJune 2018pdf fileDerek NexusSarah Nexus
Strain Profiles: Moving Beyond Binary Ames Classification - A SummaryApril 2018Sarah Nexus
Sarah Nexus Strain InformationMarch 2018pdf fileSarah Nexus
49th ICGM Product Manager UpdateMarch 2018pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaVitic NexusZeneth
Using New Features to Further Interrogate Sarah Nexus PredictionsMarch 2018pdf fileSarah Nexus
Strain profiles: Moving beyond binary Ames classificationMarch 2018pdf fileSarah Nexus
Leveraging Strain Information In Sarah Nexus PredictionsMarch 2018pdf fileSarah Nexus
ICH M7 BrochureMarch 2018pdf fileDerek NexusSarah NexusVitic NexusZeneth
Nexus 2.2: An Overview of Key New Features - Sarah NexusJanuary 2018Sarah Nexus
Sarah Nexus BrochureJanuary 2018pdf fileSarah Nexus
Lhasa Knowledge Suite Nexus 2.2 Release NotesDecember 2017pdf fileDerek NexusMeteor NexusSarah Nexus
Lhasa Knowledge Suite Nexus 2.2 Installation GuideDecember 2017pdf fileDerek NexusMeteor NexusSarah Nexus
What would you do? 47th and 48th ICGMsNovember 2017pdf fileSarah NexusDerek Nexus
Sarah Nexus: The Statistical System for ICH M7November 2017pdf fileSarah Nexus
Manual and Computational Methods for the Evaluation of Statistical Predictions Based on Expert AnalysisOctober 2017pdf fileDerek NexusSarah Nexus
Applicability of in silico genotoxicity models on food and feed ingredientsOctober 2017Derek NexusSarah Nexus
Manual and Computational Methods for the Evaluation of Statistical Predictions Based on Expert AnalysisOctober 2017pdf fileDerek NexusSarah Nexus
Dealing with Out of Domain (Q)SAR Predictions for ICH M7: A Regulatory and Industrial PerspectiveSeptember 2017Derek NexusSarah Nexus
Improving Chemical Space Coverage of an In Silico Prediction System by Targeted Inclusion of Fragments Absent from the Training SetSeptember 2017pdf fileIntermediatesSarah NexusVitic Nexus
Utility of Published DNA reactivity alertsMay 2017Derek NexusSarah Nexus
Japanese ICH M7 ExamplesMay 2017pdf fileDerek NexusSarah NexusVitic Nexus
Carbamates and ICH M7 classification: Making use of expert knowledgeApril 2017Derek NexusSarah Nexus
ICH M7 Classification WorkflowMarch 2017pdf fileDerek NexusSarah Nexus
46th ICGM Product Manager UpdateMarch 2017pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaVitic NexusZeneth
Sarah Confidence and Model Building - The How, What and WhyMarch 2017pdf fileSarah Nexus
Expert review of the mutagenicity of carbamates - using (Q)SAR predictions for ICH M7 classificationMarch 2017pdf fileDerek NexusSarah NexusVitic Nexus
Regulatory Submission Under ICH M7 - Application of Expert ReviewMarch 2017pdf fileDerek NexusSarah Nexus
In Silico Strategies to Assess Potentially Mutagenic Impurities Under ICH M7March 2017pdf fileDerek NexusSarah NexusMirabilisVitic Nexus
Computational Systems Pharmacology and Toxicology - Tools for Green Molecular Design to Reduce Toxicological RiskMarch 2017Derek NexusSarah Nexus
Using Sarah Nexus Effectively: Intuitive Model Building and Interpreting ConfidenceFebruary 2017Sarah Nexus
A comparison of Derek and Sarah NexusFebruary 2017pdf fileDerek NexusSarah Nexus
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substancesFebruary 2017Derek NexusSarah Nexus
Distinguishing between expert and statistical systems for application under ICH M7January 2017Derek NexusSarah Nexus
Advantages in Utilizing an Integrated In Silico Solution for ICH M7 Expert ReviewNovember 2016pdf fileDerek NexusMeteor NexusSarah NexusVitic NexusZeneth
The Liability Load and how Lhasa Limited Focuses on Reducing itNovember 2016pdf fileDerek NexusSarah Nexus
A k-Nearest Neighbours Approach Using Metabolism-related Fingerprints to Improve In Silico Metabolite RankingNovember 2016Meteor NexusSarah Nexus
Derek and Sarah for WebOctober 2016pdf fileSarah NexusDerek Nexus
Intuitive Model Building with Sarah NexusOctober 2016pdf fileSarah Nexus
Product Update 44th ICGMOctober 2016pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaZeneth
ICH M7 Classification and the involvement of (Q)SAR methodsOctober 2016pdf fileDerek NexusSarah Nexus
Are these alerting structures an appropriate aid in the expert analysis of two complementary QSAR predictions?October 2016Derek NexusSarah Nexus
Carbamates, QSAR predictions and ICH M7 classification; making use of expert knowledgeOctober 2016Derek NexusSarah Nexus
Confidence and Accuracy in Sarah NexusSeptember 2016pdf fileSarah Nexus
An Automated Classification Workflow to Assist Expert Assessment and Regulatory Submission for ICH M7August 2016pdf fileDerek NexusSarah Nexus
3-Fluoro-4-Phenylaniline - Positive - PositiveAugust 2016Derek NexusSarah Nexus
Phenyltrifluoroborate - Positive - Out Of DomainAugust 2016Derek NexusSarah Nexus
N-Propyl Triazoline - Positive - NegativeAugust 2016Derek NexusSarah Nexus
Methyl Sulfate - Negative - EquivocalAugust 2016Derek NexusSarah Nexus
Tolfenamic Acid - Negative - NegativeAugust 2016Derek NexusSarah Nexus
Data Dos and Don'ts in Building Statistical Models For Ames MutagenicityJune 2016pdf fileSarah Nexus
The use of in silico tools to support expert review under ICH M7June 2016pdf fileDerek NexusSarah Nexus
Mutagenicity Prediction Using In Silico Methods: Gigabyte-Sized Petri DishesJune 2016pdf fileDerek NexusZenethVitic NexusSarah NexusMirabilisMeteor Nexus
Sarah Nexus Mutagenicity QMRF.pdfMay 2016pdf fileSarah Nexus
Evaluation Of The Statistics-Based Ames Mutagenicity Model Sarah Nexus And Interpretation Of The Results ObtainedApril 2016Sarah Nexus
ICH M7 - Worked Examples using the new Nexus workflowMarch 2016pdf fileDerek NexusSarah Nexus
43rd ICGM Product UpdateMarch 2016pdf fileSarah NexusVitic NexusDerek NexusIntermediatesExcipientsMeteor NexusZenethSetaria
Mutagenic impurities: predicting alerting structures using in silico toolsMarch 2016pdf fileSarah NexusDerek Nexus
Implementation of ICH M7 Recommended (Q)SAR AnalysesMarch 2016pdf fileDerek NexusSarah NexusVitic NexusZeneth
Advantages in Utilizing an Integrated In Silico Solution for ICH M7 Expert ReviewMarch 2016pdf fileDerek NexusMirabilisSarah NexusVitic NexusZeneth
Lhasa Knowledge Suite - Nexus 2.1 Release NotesMarch 2016pdf fileDerek NexusMeteor NexusSarah Nexus
Lhasa Knowledge Suite - Nexus 2.1 Installation GuideJanuary 2016pdf fileDerek NexusMeteor NexusSarah Nexus
Undertaking Expert Review under ICH M7 - A Practical GuideDecember 2015pdf fileDerek NexusSarah Nexus
Evaluation Of A Statistics-based Ames Mutagenicity QSAR Model And Interpretation Of The Results ObtainedDecember 2015Sarah Nexus
Important Considerations When Building Statistical-based Mutagenicity Models.pdfNovember 2015pdf fileSarah Nexus
Mutagenicity assessment strategy for pharmaceutical intermediates to aid limit setting for occupational exposureNovember 2015Sarah NexusDerek Nexus
Establishing best practise in the application of expert review of mutagenicity under ICH M7August 2015Derek NexusSarah Nexus
Mutagenic Impurities: Precompetitive/Competitive Collaborative and Data Sharing InitiativesMay 2015Derek NexusExcipientsIntermediatesMirabilisSarah NexusVitic NexusZeneth
A practical application of two in silico systems for identification of potentially mutagenic impuritiesMay 2015Derek NexusSarah Nexus
Nexus 2 - Improved functionality to assist in ICH M7 submissionDecember 2014Derek NexusSarah Nexus
Introduction to in silico toxicologyOctober 2014Derek NexusSarah Nexus
Self organising hypothesis networks: a new approach for representing and structuring SAR knowledgeMay 2014Sarah Nexus
How Sarah Nexus PredictsMarch 2014Sarah Nexus
Benchmarking Assessment of Salmonella Mutagenicity QSAR Models for Potential Use Under ICH M7.pdfMarch 2014pdf fileSarah Nexus

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