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Derek NexusDerek Nexus Publications

The following links provide access to relevant Derek Nexus publications for the last 2 years. If you would like to view older publications, or to refine your search criteria further please search the library.

TitlePublishedTypeProducts
A Defined Approach to Skin Sensitisation: Integrating Derek Nexus with In Chemico/In Vitro Assays - A SummaryApril 2018Derek NexusVitic Nexus
Derek Nexus and the Prediction of Human Skin Sensitisation Potential - A SummaryApril 2018Derek Nexus
Addressing the Challenge of Making Negative Predictions for Skin Sensitisation - A SummaryApril 2018Derek Nexus
Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approachMarch 2018Derek NexusVitic Nexus
49th ICGM Product Manager UpdateMarch 2018pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaVitic NexusZeneth
An Overview of Recent Skin Sensitisation Work at LhasaMarch 2018pdf fileDerek Nexus
Addressing the Challenge of Making Negative Predictions for Skin SensitisationMarch 2018pdf fileDerek Nexus
Derek Nexus and the Prediction of Human Skin Sensitisation Potential: An EvaluationMarch 2018pdf fileDerek Nexus
A Defined Approach to Skin Sensitization Using Derek Nexus and Non-Animal AssaysMarch 2018pdf fileDerek Nexus
Skin sensitisation - What place does in silico have within a defined approach?March 2018pdf fileDerek Nexus
ICH M7 BrochureMarch 2018pdf fileDerek NexusSarah NexusVitic NexusZeneth
Setaria 1.2 Installation GuideFebruary 2018pdf fileDerek NexusSetaria
Setaria 1.2 Release NotesFebruary 2018pdf fileDerek NexusSetaria
Nexus 2.2: An Overview of Key New Features - Derek and Meteor NexusJanuary 2018Derek NexusMeteor Nexus
Derek Web Service 6.0 Installation GuideJanuary 2018pdf fileDerek Nexus
Derek Web Service 6.0 Release NotesJanuary 2018pdf fileDerek Nexus
Derek Web Service 6.0 User GuideJanuary 2018pdf fileDerek Nexus
Derek Web Service 6.0 DX-XML Results FormatJanuary 2018pdf fileDerek Nexus
Derek Web Services 6.0 Pipeline Pilot Installation and User GuideJanuary 2018pdf fileDerek Nexus
EC3: Methodology ExplainedJanuary 2018pdf fileDerek Nexus
Derek Nexus BrochureJanuary 2018pdf fileDerek Nexus
Skin Sensitsation BrochureJanuary 2018pdf fileDerek NexusVitic Nexus
Derek Nexus Carcinogenicity QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus Chromosome Damage QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus Mutagenicity QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus Skin Sensitisation QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus HERG QMRF.pdfDecember 2017pdf fileDerek Nexus
Lhasa Knowledge Suite Nexus 2.2 Release NotesDecember 2017pdf fileDerek NexusMeteor NexusSarah Nexus
Lhasa Knowledge Suite Nexus 2.2 Installation GuideDecember 2017pdf fileDerek NexusMeteor NexusSarah Nexus
Lhasa Knowledge Suite Nexus 2.2 Data Set References for Validation CommentsDecember 2017pdf fileDerek Nexus
Derek Nexus Teratogenicity QMRF.pdfDecember 2017pdf fileDerek Nexus
What would you do? 47th and 48th ICGMsNovember 2017pdf fileSarah NexusDerek Nexus
Understanding Negative Predictions in Derek Nexus - A Detailed WorkflowNovember 2017pdf fileDerek Nexus
Understanding Negative Predictions in Derek NexusNovember 2017pdf fileDerek Nexus
An Overview of Lhasa Limited Collaborative Data Sharing InitiativesOctober 2017pdf fileDerek NexusETOXExcipientsIntermediatesVitic Nexus
Advances in In Silico Skin Sensitisation Predictions Using Derek NexusOctober 2017pdf fileDerek Nexus
Negative Predictions for Skin Sensitisation 47th ICGMOctober 2017pdf fileDerek Nexus
Manual and Computational Methods for the Evaluation of Statistical Predictions Based on Expert AnalysisOctober 2017pdf fileDerek NexusSarah Nexus
Applicability of in silico genotoxicity models on food and feed ingredientsOctober 2017Derek NexusSarah Nexus
Alternatives to in vivo testing for plant protection productsOctober 2017pdf fileDerek Nexus
Manual and Computational Methods for the Evaluation of Statistical Predictions Based on Expert AnalysisOctober 2017pdf fileDerek NexusSarah Nexus
Dealing with Out of Domain (Q)SAR Predictions for ICH M7: A Regulatory and Industrial PerspectiveSeptember 2017Derek NexusSarah Nexus
In silico prediction of the skin sensitisation potential of non-quinonoid Michael acceptors: new reactivity assessments and evidence based precursor selectionSeptember 2017pdf fileDerek Nexus
Expert Review of In Silico Predictions for Skin Sensitization PotencySeptember 2017pdf fileDerek Nexus
Getting under the skin of an in silico approach to predicting dermal sensitisationAugust 2017pdf fileDerek Nexus
Integrated hazard identification of chemical sensitizers using in vitro and in silico readouts - A comparative evaluation of predictive performanceAugust 2017pdf fileDerek Nexus
Extrapolation of in vitro mutagenicity alerts to the in vivo endpoint in Derek NexusAugust 2017pdf fileDerek Nexus
A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategiesAugust 2017Derek NexusMeteor NexusMirabilisVitic Nexus
Utility of Published DNA reactivity alertsMay 2017Derek NexusSarah Nexus
Japanese ICH M7 ExamplesMay 2017pdf fileDerek NexusSarah NexusVitic Nexus
Nothing to report? An in silico fragmentation methodology for making explicit negative predictions of skin sensitisationMay 2017pdf fileDerek Nexus
Negative Predictions for Skin SensitisationApril 2017Derek Nexus
Expert Review of EC3 PredictionsApril 2017Derek Nexus
Carbamates and ICH M7 classification: Making use of expert knowledgeApril 2017Derek NexusSarah Nexus
ICH M7 Classification WorkflowMarch 2017pdf fileDerek NexusSarah Nexus
A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure–activity alert spacesMarch 2017Derek Nexus
46th ICGM Product Manager UpdateMarch 2017pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaVitic NexusZeneth
Negative Predictions for Skin Sensitisation 46th ICGMMarch 2017pdf fileDerek Nexus
Workbook: Expert Review of EC3 Predictions - a workshopMarch 2017pdf fileDerek Nexus
How important is expert review when measuring EC3 predictions in Derek Nexus?: Alkyl halides - a case studyMarch 2017pdf fileDerek Nexus
Developmental and Reproductive Toxicity Predictions in Derek NexusMarch 2017pdf fileDerek Nexus
Performance of Derek Nexus’ In Silico EC3 Model for Predicting Dermal Sensitization PotencyMarch 2017pdf fileDerek Nexus
Utilization Of Derek Nexus Dermal Sensitization Predictions For Hazard Assessment At Bristol-Myers SquibbMarch 2017pdf fileDerek Nexus
Expert review of the mutagenicity of carbamates - using (Q)SAR predictions for ICH M7 classificationMarch 2017pdf fileDerek NexusSarah NexusVitic Nexus
Regulatory Submission Under ICH M7 - Application of Expert ReviewMarch 2017pdf fileDerek NexusSarah Nexus
In Silico Strategies to Assess Potentially Mutagenic Impurities Under ICH M7March 2017pdf fileDerek NexusSarah NexusMirabilisVitic Nexus
Computational Systems Pharmacology and Toxicology - Tools for Green Molecular Design to Reduce Toxicological RiskMarch 2017Derek NexusSarah Nexus
A comparison of Derek and Sarah NexusFebruary 2017pdf fileDerek NexusSarah Nexus
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substancesFebruary 2017Derek NexusSarah Nexus
Distinguishing between expert and statistical systems for application under ICH M7January 2017Derek NexusSarah Nexus
Derek Product PosterDecember 2016pdf fileDerek Nexus
Drawing Conventions.pdfNovember 2016pdf fileDerek Nexus
Advantages in Utilizing an Integrated In Silico Solution for ICH M7 Expert ReviewNovember 2016pdf fileDerek NexusMeteor NexusSarah NexusVitic NexusZeneth
The Liability Load and how Lhasa Limited Focuses on Reducing itNovember 2016pdf fileDerek NexusSarah Nexus
Can in silico models be used in place of the LLNA to predict the skin sensitisation of cosmeticsNovember 2016pdf fileDerek Nexus
Derek and Sarah for WebOctober 2016pdf fileSarah NexusDerek Nexus
Product Update 44th ICGMOctober 2016pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaZeneth
Skin Sensitisation - Negative Predictions, Validations and Integrated Testing StrategiesOctober 2016pdf fileDerek Nexus
ICH M7 Classification and the involvement of (Q)SAR methodsOctober 2016pdf fileDerek NexusSarah Nexus
Refining the prediction of skin sensitisation potential: performance of the Derek Nexus knowledge base for a published datasetOctober 2016pdf fileDerek Nexus
How to discover new structural alerts and recognise new secondary molecular attributes that modulate alert effectivenessOctober 2016pdf fileDerek Nexus
Are these alerting structures an appropriate aid in the expert analysis of two complementary QSAR predictions?October 2016Derek NexusSarah Nexus
Carbamates, QSAR predictions and ICH M7 classification; making use of expert knowledgeOctober 2016Derek NexusSarah Nexus
An Automated Classification Workflow to Assist Expert Assessment and Regulatory Submission for ICH M7August 2016pdf fileDerek NexusSarah Nexus
3-Fluoro-4-Phenylaniline - Positive - PositiveAugust 2016Derek NexusSarah Nexus
Phenyltrifluoroborate - Positive - Out Of DomainAugust 2016Derek NexusSarah Nexus
N-Propyl Triazoline - Positive - NegativeAugust 2016Derek NexusSarah Nexus
Methyl Sulfate - Negative - EquivocalAugust 2016Derek NexusSarah Nexus
Tolfenamic Acid - Negative - NegativeAugust 2016Derek NexusSarah Nexus
Developing expert in silico systemsJune 2016pdf fileDerek NexusMeteor Nexus
The use of in silico tools to support expert review under ICH M7June 2016pdf fileDerek NexusSarah Nexus
Mutagenicity Prediction Using In Silico Methods: Gigabyte-Sized Petri DishesJune 2016pdf fileDerek NexusZenethVitic NexusSarah NexusMirabilisMeteor Nexus
Is preclinical data sharing the new norm?May 2016Derek NexusETOXExcipientsIntermediatesMeteor NexusVitic Nexus
Using Derek Nexus to assess the safety of raw materials used in cosmeticsMay 2016Derek Nexus
Using Derek Nexus as part of a skin sensitisation integrated testing strategy (ITS)May 2016Derek Nexus
Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assaysApril 2016pdf fileDerek Nexus
Improvements to in silico predictivity after access to proprietary dataApril 2016Derek Nexus
Mechanistic Expert Call Datasets Support in silico Prediction of Teratogenicity for a Wider Chemical SpaceApril 2016Derek Nexus
Quantitative prediction of skin sensitisation potency based on structural alert spacesApril 2016Derek Nexus
Lhasa Data Sharing Experience at Bristol-Myers SquibbApril 2016pdf fileDerek Nexus
ICH M7 - Worked Examples using the new Nexus workflowMarch 2016pdf fileDerek NexusSarah Nexus
43rd ICGM Product UpdateMarch 2016pdf fileSarah NexusVitic NexusDerek NexusIntermediatesExcipientsMeteor NexusZenethSetaria
Skin sensitisation: Now and the FutureMarch 2016pdf fileDerek Nexus
Skin sensitisation: The implementation of potency predictions in Derek NexusMarch 2016pdf fileDerek Nexus
Mutagenic impurities: predicting alerting structures using in silico toolsMarch 2016pdf fileSarah NexusDerek Nexus
Mechanistic Expert Call Datasets Provide In Silico Prediction of Teratogenicity for a Wider Chemical SpaceMarch 2016pdf fileDerek Nexus
Quantitative prediction of skin sensitisation potency based on structural alert spacesMarch 2016pdf fileDerek Nexus
Improvements to In Silico Skin Sensitization Predictivity After Access to Proprietary DataMarch 2016pdf fileDerek Nexus
Improvements to in silico mutagenicity predictivity of aromatic amines with access to proprietary dataMarch 2016pdf fileDerek Nexus
Implementation of ICH M7 Recommended (Q)SAR AnalysesMarch 2016pdf fileDerek NexusSarah NexusVitic NexusZeneth
Advantages in Utilizing an Integrated In Silico Solution for ICH M7 Expert ReviewMarch 2016pdf fileDerek NexusMirabilisSarah NexusVitic NexusZeneth
Lhasa Knowledge Suite - Nexus 2.1 Release NotesMarch 2016pdf fileDerek NexusMeteor NexusSarah Nexus
Mutagenicity assessment strategy for pharmaceutical intermediates to aid limit setting for occupational exposureJanuary 2016Sarah NexusDerek Nexus
Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assaysJanuary 2016Derek Nexus
It’s difficult, but important, to make negative predictionsJanuary 2016Derek Nexus
Lhasa Knowledge Suite - Nexus 2.1 Installation GuideJanuary 2016pdf fileDerek NexusMeteor NexusSarah Nexus

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