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Derek NexusDerek Nexus Publications

The following links provide access to relevant Derek Nexus publications for the last 2 years. If you would like to view older publications, or to refine your search criteria further please search the library.

TitlePublishedTypeProducts
An Evaluation of the Occupational Health Hazards of Peptide CouplersMay 2022Derek Nexus
Assessment of the dermal sensitisation potency of extractables and leachables using existing data and in silico methodsApril 2022pdf fileVitic NexusDerek Nexus
Updated Dermal Sensitisation Thresholds derived using an in silico expert system and an expanded Local Lymph Node Assay datasetApril 2022pdf fileDerek Nexus
Validation statistics for negative predictions in Derek Nexus 2022 1.0April 2022pdf fileDerek Nexus
Chapter 3: Control Strategies for Mutagenic ImpuritiesMarch 2022MirabilisDerek NexusSarah Nexus
Chapter 9: Mutagenic Impurities – Assessment of Fate and Control OptionsMarch 2022Derek NexusSarah NexusMirabilis
Chapter 17: Use of Lhasa Limited Products for the In Silico Prediction of Drug ToxicityFebruary 2022Derek NexusSarah NexusMirabilisZeneth
Chapter 7: Compound- and Class-Specific Limits for Common Impurities in PharmaceuticalsFebruary 2022Derek NexusSarah NexusMirabilis
Developing structure-activity relationships for N-nitrosamine activityNovember 2021Derek Nexus
How carboxylic and sulfonic acid halides are represented within Derek Nexus and Sarah NexusOctober 2021pdf fileDerek NexusSarah Nexus
In Silico Prediction of Genotoxicity Current Applications and Future PerspectivesSeptember 2021pdf fileDerek NexusSarah Nexus
QSAR 2021 Addressing the global challenge of N-nitrosamine impurity assessmentJune 2021pdf fileDerek NexusMirabilisSarah NexusVitic Nexus
Predicting N-Nitrosamine Activity from SARJune 2021pdf fileDerek NexusSarah Nexus
Development of an Adverse Outcome Pathway Network to Support an Integrated Approach to Testing and Assessment of Carcinogenic Risk - SOT 2021 Presentation SlidesMarch 2021pdf fileDerek Nexus
Nexus ICH M7 Expert Review Support Functionality (an infographic)December 2020pdf fileDerek NexusSarah Nexus
Management of pharmaceutical ICH M7 (Q)SAR predictions – The impact of model updatesNovember 2020Derek NexusSarah NexusVitic Nexus
The importance of expert review to clarify ambiguous situations for (Q)SAR predictions under ICH M7September 2020Derek NexusSarah Nexus
Integrating Knowledge Of Carcinogenicity Adverse Outcome Pathways (AOPs) With Experimental Data_EMGS Data Challenge 2020September 2020pdf fileDerek NexusVitic Nexus
ICH M7 Expert Review Workshop: Resolving common prediction scenarios using automated arguments in Nexus 2.3 (Webinar Presentation Slides)September 2020pdf fileDerek NexusSarah Nexus
Derek Nexus - Achieving High Accuracy with High CoverageSeptember 2020pdf fileDerek Nexus
Are all nitrosamines concerning? A review of mutagenicity and carcinogenicity dataSeptember 2020Derek NexusSarah NexusVitic Nexus
Do all nitrosamines pose a significant level of genotoxic risk? (Webinar Presentation Slides)July 2020pdf fileDerek NexusSarah Nexus
ICH M7 Workshop Japanese ICGM 2019July 2020pdf fileSetariaSarah NexusMirabilisVitic NexusDerek Nexus
Lhasa Knowledge Suite Nexus 2.3 Release NotesJune 2020pdf fileDerek NexusSarah Nexus
Derek Nexus Carcinogenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Chromosome Damage QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Mutagenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Skin Sensitisation QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus HERG QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Teratogenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Evaluation of the Global Performance of Eight In Silico Skin Sensitization Models Using Human DataMay 2020Derek Nexus
The application of in silico models to support decision making in toxicologyMay 2020pdf fileDerek NexusSetariaVitic NexusZenethMirabilisSarah Nexus
In silico workflow under ICH M7March 2020pdf fileDerek NexusSetariaVitic NexusSarah Nexus
Comparing and combining in silico outcomes and in vitro mechanism-based assays to predict genotoxicityMarch 2020pdf fileDerek NexusVitic Nexus
Updated Dermal Sensitisation Thresholds derived using an in silico expert system and an expanded Local Lymph Node Assay datasetMarch 2020pdf fileDerek NexusVitic Nexus
Generation of novel in chemico in vitro skin sensitisation data to evaluate the human relevance of defined approachesMarch 2020pdf fileDerek Nexus
Validating proposed improvements to phototoxicity expert alerts against proprietary dataMarch 2020pdf fileDerek Nexus
ICH M7 Workshop - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah NexusZenethVitic NexusSetariaMirabilis
Predictions, Data and ICH M7 - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah NexusVitic NexusSetaria
Lhasa and the ICH M7 Guideline - 2020 ICH M7 India RoadshowMarch 2020pdf fileDerek NexusSarah NexusVitic NexusSetariaMirabilis
GSK MI risk assessment process Camicinal at al - 2020 ICH M7 India RoadshowMarch 2020pdf fileDerek NexusSarah NexusVitic Nexus
Hazard Assessment of Potentially Mutagenic Impurities - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah Nexus
ICH M7 - Regulatory Updates and Industry Practices - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah Nexus
Lhasa Expert Review Developments - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah NexusVitic Nexus

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