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Derek NexusVitic Nexus Publications

The following links provide access to relevant Vitic Nexus publications for the last 2 years. If you would like to view older publications, or to refine your search criteria further please search the library.

TitlePublishedTypeProducts
QSAR 2021 Addressing the global challenge of N-nitrosamine impurity assessmentJune 2021pdf fileDerek NexusMirabilisSarah NexusVitic Nexus
Predicting N-Nitrosamine Activity from SARJune 2021pdf fileDerek NexusSarah Nexus
Development of an Adverse Outcome Pathway Network to Support an Integrated Approach to Testing and Assessment of Carcinogenic Risk - SOT 2021 Presentation SlidesMarch 2021pdf fileDerek Nexus
Nexus ICH M7 Expert Review Support Functionality (an infographic)December 2020pdf fileDerek NexusSarah Nexus
Management of pharmaceutical ICH M7 (Q)SAR predictions – The impact of model updatesNovember 2020Derek NexusSarah NexusVitic Nexus
The importance of expert review to clarify ambiguous situations for (Q)SAR predictions under ICH M7September 2020Derek NexusSarah Nexus
Integrating Knowledge Of Carcinogenicity Adverse Outcome Pathways (AOPs) With Experimental Data_EMGS Data Challenge 2020September 2020pdf fileDerek NexusVitic Nexus
ICH M7 Expert Review Workshop: Resolving common prediction scenarios using automated arguments in Nexus 2.3 (Webinar Presentation Slides)September 2020pdf fileDerek NexusSarah Nexus
Derek Nexus - Achieving High Accuracy with High CoverageSeptember 2020pdf fileDerek Nexus
Are all nitrosamines concerning? A review of mutagenicity and carcinogenicity dataSeptember 2020Derek NexusSarah NexusVitic Nexus
Do all nitrosamines pose a significant level of genotoxic risk? (Webinar Presentation Slides)July 2020pdf fileDerek NexusSarah Nexus
ICH M7 Workshop Japanese ICGM 2019July 2020pdf fileSetariaSarah NexusMirabilisVitic NexusDerek Nexus
Lhasa Knowledge Suite Nexus 2.3 Release NotesJune 2020pdf fileDerek NexusSarah Nexus
Derek Nexus Carcinogenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Chromosome Damage QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Mutagenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Skin Sensitisation QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus HERG QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Teratogenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Evaluation of the Global Performance of Eight In Silico Skin Sensitization Models Using Human DataMay 2020Derek Nexus
The application of in silico models to support decision making in toxicologyMay 2020pdf fileDerek NexusSetariaVitic NexusZenethMirabilisSarah Nexus
In silico workflow under ICH M7March 2020pdf fileDerek NexusSetariaVitic NexusSarah Nexus
Comparing and combining in silico outcomes and in vitro mechanism-based assays to predict genotoxicityMarch 2020pdf fileDerek NexusVitic Nexus
Updated Dermal Sensitisation Thresholds derived using an in silico expert system and an expanded Local Lymph Node Assay datasetMarch 2020pdf fileDerek NexusVitic Nexus
Generation of novel in chemico in vitro skin sensitisation data to evaluate the human relevance of defined approachesMarch 2020pdf fileDerek Nexus
Validating proposed improvements to phototoxicity expert alerts against proprietary dataMarch 2020pdf fileDerek Nexus
ICH M7 Workshop - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah NexusZenethVitic NexusSetariaMirabilis
Predictions, Data and ICH M7 - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah NexusVitic NexusSetaria
Lhasa and the ICH M7 Guideline - 2020 ICH M7 India RoadshowMarch 2020pdf fileDerek NexusSarah NexusVitic NexusSetariaMirabilis
GSK MI risk assessment process Camicinal at al - 2020 ICH M7 India RoadshowMarch 2020pdf fileDerek NexusSarah NexusVitic Nexus
Hazard Assessment of Potentially Mutagenic Impurities - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah Nexus
ICH M7 - Regulatory Updates and Industry Practices - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah Nexus
Lhasa Expert Review Developments - 2020 ICH M7 India RoadshowsMarch 2020pdf fileDerek NexusSarah NexusVitic Nexus
Carcinogenicity Adverse Outcome PathwaysJanuary 2020pdf fileDerek NexusVitic Nexus
Beyond Mutagenicity: Supporting Toxicity Assessments For Other EndpointsJanuary 2020pdf fileDerek Nexus
Approaches to Skin Sensitisation PredictionNovember 2019pdf fileDerek Nexus
Data Sharing with LhasaNovember 2019pdf fileDerek Nexus
Improving performance of structural alerts for the in vitro mutagenicity endpoint using proprietary data - Rachael TennantNovember 2019pdf fileDerek Nexus
Achieving Innovation Through Collaborative ProgressNovember 2019pdf fileDerek NexusVitic NexusIntermediates
Product Update 2019November 2019pdf fileDerek NexusSarah NexusZenethVitic NexusSetariaMirabilisMeteor Nexus
Current advances in skin sensitization in silico predictions and their use in a defined approachOctober 2019pdf fileDerek Nexus
Predictive Toxicology: Using In Silico SystemsOctober 2019pdf fileDerek NexusSarah Nexus
ICH M7 - Risk assessment for mutagenic impurities and control strategiesSeptember 2019Derek NexusMirabilisSarah Nexus
Setting the basis for the mutagenicity assessment of new dyes: Application to the Max Weaver Dye LibraryAugust 2019pdf fileDerek Nexus
Toxicity Evaluation of Degradation ProductsJuly 2019pdf fileDerek NexusSarah NexusZeneth
(Q)SAR Evaluation of Drug Impurities from the US FDA Scientific PerspectiveJuly 2019pdf fileDerek NexusSarah Nexus
Managing Mutagenic Impurity Risks in Pharmaceutical ProductsJuly 2019pdf fileDerek NexusSarah Nexus
In silico prediction of MutagenicityJune 2019pdf fileSarah NexusDerek Nexus
Use of In Silico Tools for Toxicity Prediction Within ICH M7June 2019pdf fileDerek NexusSarah NexusVitic Nexus
RDC53: Challenges on impurities qualificationJune 2019pdf fileDerek NexusSarah NexusVitic NexusZeneth
Demonstration of a Defined Approach for Skin Sensitisation Web ApplicationJune 2019Derek Nexus
Introduction to Lhasa - Applying ICH M7 - What makes an expertMay 2019pdf fileDerek NexusMirabilisSarah NexusMeteor NexusVitic Nexus
Modelling Simple Toxicity Endpoints: Alerts, (Q)SARs and BeyondMay 2019Derek NexusMeteor NexusSarah NexusVitic Nexus
Applicability Domain: Towards a More Formal Framework to Express the Applicability of a Model and the Confidence in Individual PredictionsMay 2019Derek Nexus
A Suggested ICH M7 Framework Using Lhasa Limited ProductsMay 2019pdf fileZenethVitic NexusMirabilisSarah NexusDerek Nexus
A Case Study in Predicting hERG Activity.April 2019Derek NexusSarah NexusMirabilisMeteor NexusVitic NexusZenethSetaria
Improving In Silico Predictions in Developmental and Reproductive ToxicologyApril 2019Derek NexusSarah Nexus
ICH M7 Perception: Unifying Knowledge from Predictions to PurgingMarch 2019pdf fileMirabilisSetariaDerek NexusSarah NexusVitic Nexus
Development of an Adverse Outcome Pathway (AOP) Network for Carcinogenicity Using Expert-Derived (Q)SAR Knowledge. PosterMarch 2019pdf fileDerek Nexus
Looking Under the Hood – Expert Review of In Silico Carcinogenicity Predictions.March 2019pdf fileDerek Nexus
Product Update ICGM PresentationMarch 2019pdf fileDerek NexusSarah Nexus
Avoiding hERG-liability in drug design via synergetic combinations of different (Q)SAR methodologies and data sources: a case study in an industrial settingFebruary 2019Sarah NexusDerek Nexus
Advance your knowledge of ICH M7 A virtual expert review workshopFebruary 2019Derek NexusSarah Nexus
A defined approach for predicting skin sensitisation hazard and potency based on the guided integration of in silico, in chemico and in vitro data using exclusion criteriaJanuary 2019Derek NexusVitic Nexus
Developing an adverse outcome pathway framework for carcinogenicity from alerts in an expert rule-based system.December 2018Derek Nexus
The use of Derek Nexus to facilitate decision-making in chemical safety assessment.December 2018pdf fileDerek Nexus
Save Time and Money with Lhasa LimitedDecember 2018pdf fileDerek NexusSarah NexusZeneth
Welcome and Introduction to ICH M7 - ICH M7 India RoadshowsNovember 2018pdf fileDerek NexusSarah NexusVitic Nexus
Derek Nexus, Sarah Nexus and Vitic: How they fit into ICH M7 - ICH M7 India RoadshowsNovember 2018pdf fileDerek NexusSarah NexusVitic Nexus
Derek Nexus, The Expert System for ICH M7 - ICH M7 India RoadshowsNovember 2018pdf fileDerek Nexus
An adverse outcome pathway framework to support developmental and reproductive toxicity risk assessmentsNovember 2018pdf fileDerek NexusSarah NexusVitic Nexus
A Defined Approach for Predicting Skin Sensitisation Hazard and PotencyNovember 2018pdf fileDerek Nexus
Important considerations for the validation of QSAR models for in vitro mutagenicityNovember 2018Derek NexusSarah NexusVitic Nexus
Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge ProjectOctober 2018Derek NexusSarah Nexus
Extrapolation of in vitro structural alerts for mutagenicity to the in vivo endpointOctober 2018Derek Nexus
In Silico Predictions For GenotoxicityOctober 2018pdf fileDerek NexusSarah Nexus
Integrating Knowledge Of Carcinogenicity Adverse Outcome Pathways (AOPs) With Experimental DataOctober 2018pdf fileDerek NexusVitic Nexus
Meeting report, ICH M7 relevant workshop: use of (Q)SAR systems and expert judgmentSeptember 2018pdf fileDerek NexusSarah Nexus
Development Of A Network Of Adverse Outcome Pathways (AOPs) For CarcinogenicitySeptember 2018pdf fileVitic NexusDerek NexusSarah Nexus
An adverse outcome pathway framework to support the assessment of DART liabilities of compoundsSeptember 2018pdf fileDerek Nexus
Developing an adverse outcome pathway framework for carcinogenicity from alerts in an expert rule-based systemSeptember 2018pdf fileDerek Nexus
A Defined Approach to Skin Sensitisation: Integrating Derek Nexus with In Chemico/In Vitro Assays Based on Exclusion CriteriaAugust 2018pdf fileDerek Nexus
Toxicity Studies for Degradation Impurities - An Industry PerspectiveJune 2018pdf fileDerek NexusSarah Nexus
Improving Toxicity Predictions through knowledge and data sharingJune 2018pdf fileDerek NexusExcipientsIntermediatesiPiEVitic Nexus
ICH M7 Use CasesJune 2018pdf fileDerek NexusSarah Nexus
A Defined Approach to Skin Sensitisation: Integrating Derek Nexus with In Chemico/In Vitro Assays - A SummaryApril 2018Derek NexusVitic Nexus
Derek Nexus and the Prediction of Human Skin Sensitisation Potential - A SummaryApril 2018Derek Nexus
Addressing the Challenge of Making Negative Predictions for Skin Sensitisation - A SummaryApril 2018Derek Nexus
Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approachMarch 2018Derek NexusVitic Nexus
49th ICGM Product Manager UpdateMarch 2018pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaVitic NexusZeneth
An Overview of Recent Skin Sensitisation Work at LhasaMarch 2018pdf fileDerek Nexus
Addressing the Challenge of Making Negative Predictions for Skin SensitisationMarch 2018pdf fileDerek Nexus
Derek Nexus and the Prediction of Human Skin Sensitisation Potential: An EvaluationMarch 2018pdf fileDerek Nexus
A Defined Approach to Skin Sensitization Using Derek Nexus and Non-Animal AssaysMarch 2018pdf fileDerek Nexus
Skin sensitisation - What place does in silico have within a defined approach?March 2018pdf fileDerek Nexus
ICH M7 BrochureMarch 2018pdf fileDerek NexusSarah NexusVitic NexusZeneth
Setaria 1.2 Installation GuideFebruary 2018pdf fileDerek NexusSetaria
Setaria 1.2 Release NotesFebruary 2018pdf fileDerek NexusSetaria
In silico toxicity profiling of natural product compound libraries from African flora with anti-malarial and anti-HIV propertiesFebruary 2018Derek Nexus
Nexus 2.2: An Overview of Key New Features - Derek and Meteor NexusJanuary 2018Derek NexusMeteor Nexus
Derek Web Service 6.0 Installation GuideJanuary 2018pdf fileDerek Nexus
Derek Web Service 6.0 Release NotesJanuary 2018pdf fileDerek Nexus
Derek Web Service 6.0 User GuideJanuary 2018pdf fileDerek Nexus
Derek Web Service 6.0 DX-XML Results FormatJanuary 2018pdf fileDerek Nexus
Derek Web Services 6.0 Pipeline Pilot Installation and User GuideJanuary 2018pdf fileDerek Nexus
EC3: Methodology ExplainedJanuary 2018pdf fileDerek Nexus
Derek Nexus BrochureJanuary 2018pdf fileDerek Nexus
Skin Sensitisation BrochureJanuary 2018pdf fileDerek NexusVitic Nexus
Lhasa Knowledge Suite Nexus 2.2 Release NotesDecember 2017pdf fileDerek NexusMeteor NexusSarah Nexus
Lhasa Knowledge Suite Nexus 2.2 Installation GuideDecember 2017pdf fileDerek NexusMeteor NexusSarah Nexus
Lhasa Knowledge Suite Nexus 2.2 Data Set References for Validation CommentsDecember 2017pdf fileDerek Nexus
What would you do? 47th and 48th ICGMsNovember 2017pdf fileSarah NexusDerek Nexus
Understanding Negative Predictions in Derek Nexus - A Detailed WorkflowNovember 2017pdf fileDerek Nexus
Understanding Negative Predictions in Derek NexusNovember 2017pdf fileDerek Nexus
An Overview of Lhasa Limited Collaborative Data Sharing InitiativesOctober 2017pdf fileDerek NexusETOXExcipientsIntermediatesVitic NexusiPiEMeteor NexusMIP DILIMirabilisSarah NexusSetariaZeneth
Advances in In Silico Skin Sensitisation Predictions Using Derek NexusOctober 2017pdf fileDerek Nexus
Negative Predictions for Skin Sensitisation 47th ICGMOctober 2017pdf fileDerek Nexus
Manual and Computational Methods for the Evaluation of Statistical Predictions Based on Expert AnalysisOctober 2017pdf fileDerek NexusSarah Nexus
Applicability of in silico genotoxicity models on food and feed ingredientsOctober 2017Derek NexusSarah Nexus
Alternatives to in vivo testing for plant protection productsOctober 2017pdf fileDerek Nexus
Manual and Computational Methods for the Evaluation of Statistical Predictions Based on Expert AnalysisOctober 2017pdf fileDerek NexusSarah Nexus
Dealing with Out of Domain (Q)SAR Predictions for ICH M7: A Regulatory and Industrial PerspectiveSeptember 2017Derek NexusSarah Nexus
In silico prediction of the skin sensitisation potential of non-quinonoid Michael acceptors: new reactivity assessments and evidence based precursor selectionSeptember 2017pdf fileDerek Nexus
Expert Review of In Silico Predictions for Skin Sensitization PotencySeptember 2017pdf fileDerek Nexus
Getting under the skin of an in silico approach to predicting dermal sensitisationAugust 2017pdf fileDerek Nexus
Integrated hazard identification of chemical sensitizers using in vitro and in silico readouts - A comparative evaluation of predictive performanceAugust 2017pdf fileDerek Nexus
Extrapolation of in vitro mutagenicity alerts to the in vivo endpoint in Derek NexusAugust 2017pdf fileDerek Nexus
Utility of Published DNA reactivity alertsMay 2017Derek NexusSarah Nexus
Japanese ICH M7 ExamplesMay 2017pdf fileDerek NexusSarah NexusVitic Nexus
Nothing to report? An in silico fragmentation methodology for making explicit negative predictions of skin sensitisationMay 2017pdf fileDerek Nexus
Negative Predictions for Skin SensitisationApril 2017Derek Nexus
Expert Review of EC3 PredictionsApril 2017Derek Nexus
Carbamates and ICH M7 classification: Making use of expert knowledgeApril 2017Derek NexusSarah Nexus
ICH M7 Classification WorkflowMarch 2017pdf fileDerek NexusSarah Nexus
A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure–activity alert spacesMarch 2017Derek Nexus
46th ICGM Product Manager UpdateMarch 2017pdf fileDerek NexusMeteor NexusMirabilisSarah NexusSetariaVitic NexusZeneth
Negative Predictions for Skin Sensitisation 46th ICGMMarch 2017pdf fileDerek Nexus
Workbook: Expert Review of EC3 Predictions - a workshopMarch 2017pdf fileDerek Nexus
How important is expert review when measuring EC3 predictions in Derek Nexus?: Alkyl halides - a case studyMarch 2017pdf fileDerek Nexus
Developmental and Reproductive Toxicity Predictions in Derek NexusMarch 2017pdf fileDerek Nexus
Performance of Derek Nexus’ In Silico EC3 Model for Predicting Dermal Sensitization PotencyMarch 2017pdf fileDerek Nexus
Utilization Of Derek Nexus Dermal Sensitization Predictions For Hazard Assessment At Bristol-Myers SquibbMarch 2017pdf fileDerek Nexus
Expert review of the mutagenicity of carbamates - using (Q)SAR predictions for ICH M7 classificationMarch 2017pdf fileDerek NexusSarah NexusVitic Nexus
Regulatory Submission Under ICH M7 - Application of Expert ReviewMarch 2017pdf fileDerek NexusSarah Nexus
In Silico Strategies to Assess Potentially Mutagenic Impurities Under ICH M7March 2017pdf fileDerek NexusSarah NexusMirabilisVitic Nexus
Computational Systems Pharmacology and Toxicology - Tools for Green Molecular Design to Reduce Toxicological RiskMarch 2017Derek NexusSarah Nexus
A comparison of Derek and Sarah NexusFebruary 2017pdf fileDerek NexusSarah Nexus
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substancesFebruary 2017Derek NexusSarah Nexus
Distinguishing between expert and statistical systems for application under ICH M7January 2017Derek NexusSarah Nexus
Drawing Conventions.pdfNovember 2016pdf fileDerek Nexus
The Liability Load and how Lhasa Limited Focuses on Reducing itNovember 2016pdf fileDerek NexusSarah Nexus
Skin Sensitisation - Negative Predictions, Validations and Integrated Testing StrategiesOctober 2016pdf fileDerek Nexus
Are these alerting structures an appropriate aid in the expert analysis of two complementary QSAR predictions?October 2016Derek NexusSarah Nexus
Carbamates, QSAR predictions and ICH M7 classification; making use of expert knowledgeOctober 2016Derek NexusSarah Nexus
An Automated Classification Workflow to Assist Expert Assessment and Regulatory Submission for ICH M7August 2016pdf fileDerek NexusSarah Nexus
3-Fluoro-4-Phenylaniline - Positive - PositiveAugust 2016Derek NexusSarah Nexus
Phenyltrifluoroborate - Positive - Out Of DomainAugust 2016Derek NexusSarah Nexus
N-Propyl Triazoline - Positive - NegativeAugust 2016Derek NexusSarah Nexus
Methyl Sulfate - Negative - EquivocalAugust 2016Derek NexusSarah Nexus
Tolfenamic Acid - Negative - NegativeAugust 2016Derek NexusSarah Nexus
Mutagenicity Prediction Using In Silico Methods: Gigabyte-Sized Petri DishesJune 2016pdf fileDerek NexusZenethVitic NexusSarah NexusMirabilisMeteor Nexus
Is preclinical data sharing the new norm?May 2016Derek NexusETOXExcipientsIntermediatesMeteor NexusVitic Nexus
Using Derek Nexus to assess the safety of raw materials used in cosmeticsMay 2016Derek Nexus
Using Derek Nexus as part of a skin sensitisation integrated testing strategy (ITS)May 2016Derek Nexus
Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assaysApril 2016pdf fileDerek Nexus
Improvements to in silico predictivity after access to proprietary dataApril 2016Derek Nexus
Mechanistic Expert Call Datasets Support in silico Prediction of Teratogenicity for a Wider Chemical SpaceApril 2016Derek Nexus
Quantitative prediction of skin sensitisation potency based on structural alert spacesApril 2016Derek Nexus
Skin sensitisation: Now and the FutureMarch 2016pdf fileDerek Nexus
Mutagenic impurities: predicting alerting structures using in silico toolsMarch 2016pdf fileSarah NexusDerek Nexus
Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assaysJanuary 2016Derek Nexus
It’s difficult, but important, to make negative predictionsJanuary 2016Derek Nexus
Undertaking Expert Review under ICH M7 - A Practical GuideDecember 2015pdf fileDerek NexusSarah Nexus
Why data sharing is important - a case study using proprietary mutagenicity and skin sensitisation data.pdfNovember 2015pdf fileDerek Nexus
Mutagenicity assessment strategy for pharmaceutical intermediates to aid limit setting for occupational exposureNovember 2015Sarah NexusDerek Nexus
Establishing best practise in the application of expert review of mutagenicity under ICH M7August 2015Derek NexusSarah Nexus
Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testingJuly 2015Derek Nexus
Relationship between the mutagenicity of arylboronic acids and 11B NMR chemical shiftsMay 2015Derek Nexus
Mutagenic Impurities: Precompetitive/Competitive Collaborative and Data Sharing InitiativesMay 2015Derek NexusExcipientsIntermediatesMirabilisSarah NexusVitic NexusZeneth
A practical application of two in silico systems for identification of potentially mutagenic impuritiesMay 2015Derek NexusSarah Nexus
An evaluation of in-house and off-the-shelf in silico models: Implications on guidance for mutagenicity assessmentApril 2015Derek Nexus
New structural alerts for Ames mutagenicity discovered using emerging pattern mining techniquesJanuary 2015Derek Nexus
Prediction of genotoxic potential of cosmetic ingredients by an in silico battery system consisting of a combination of an expert rule-based system and a statistics-based systemJanuary 2015Derek Nexus
Nexus 2 - Improved functionality to assist in ICH M7 submissionDecember 2014Derek NexusSarah Nexus
Introduction to in silico toxicologyOctober 2014Derek NexusSarah Nexus
Addressing toxicity risk when designing and selecting compounds in early drug discoveryJanuary 2014Derek Nexus

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