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Toxicity Publications

The following links provide access to relevant Toxicity publications for the last 2 years. If you would like to view older publications, or to refine your search criteria further please search the library.

Collaborative analysis of complex nitrosaminesApril 2022pdf file
The Role of Expert Assessment and In Silico Predictions in Determining Genotoxic Risk of N-Nitrosamine ImpuritiesApril 2022pdf file
Using Data Associated with a Developmental and Reproductive Toxicity Adverse Outcome Network to Aid Safety AssessmentsApril 2022pdf file
Validation statistics for negative predictions in Derek Nexus 2022 1.0April 2022pdf fileDerek Nexus
Developing structure-activity relationships for N-nitrosamine activityNovember 2021Derek Nexus
Structural features affecting nitrosamine carcinogenic potencySeptember 2021pdf file
In Silico Prediction of Genotoxicity Current Applications and Future PerspectivesSeptember 2021pdf fileDerek NexusSarah Nexus
2021 Webinar | Accessing vital sources of long-term carcinogenicity study data with Lhasa’s Carcinogenicity Database – An update and an overview - RecordingJuly 2021
2021 Webinar | Accessing vital sources of long-term carcinogenicity study data with Lhasa’s Carcinogenicity Database – An update and an overview - SlidesJuly 2021pdf file
QSAR 2021 Addressing the global challenge of N-nitrosamine impurity assessmentJune 2021pdf fileDerek NexusMirabilisSarah NexusVitic Nexus
QSAR 2021 - leveraging data from multiple sources to build QSARs through curation and federated learning in Effiris.June 2021pdf file
Predicting N-Nitrosamine Activity from SARJune 2021pdf fileDerek NexusSarah Nexus
Managing the risk of nitrosamine impuritiesJune 2021
The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and PerspectivesMarch 2021
Case study on the use of integrated approaches to testing and assessment for the prediction of a 90-day repeated dose toxicity study (OECD 408) for 2-Ethylbutyric acid using a read-across approach from other branched carboxylic acids.March 2021
Guidelines for FAIR sharing of preclinical safety and off-target pharmacology dataMarch 2021
2021 Webinar - An overview of Effiris 2.1; An enhanced qualitative model suite for anticipating and mitigating adverse drug reactions – Slides and recordingFebruary 2021pdf file
Utilisation of parametric methods to improve percentile-based estimates for the carcinogenic potency of nitrosaminesFebruary 2021
Beyond adverse outcome pathways: making toxicity predictions from event networks, SAR models, data and knowledgeJanuary 2021
Development of an Adverse Outcome Pathway Network to Support an Integrated Approach to Testing and Assessment of Carcinogenic RiskDecember 2020pdf file
Application of adverse outcome pathways (AOPs) to support genotoxicity assessmentNovember 2020pdf file
Introducing the concept of virtual control groups into preclinical toxicology testingSeptember 2020ETOX
Are all nitrosamines concerning? A review of mutagenicity and carcinogenicity dataSeptember 2020Derek NexusSarah NexusVitic Nexus
Pathways for N-nitroso compound formation: secondary amines and beyondJuly 2020
Do all nitrosamines pose a significant level of genotoxic risk? (Webinar Presentation Slides)July 2020pdf fileDerek NexusSarah Nexus
Derek Nexus Carcinogenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Chromosome Damage QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Mutagenicity QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus Skin Sensitisation QMRF.pdfJune 2020pdf fileDerek Nexus
Derek Nexus HERG QMRF.pdfJune 2020pdf fileDerek Nexus
Sarah Nexus Mutagenicity QMRF.pdfJune 2020pdf fileSarah Nexus
Derek Nexus Teratogenicity QMRF.pdfJune 2020pdf fileDerek Nexus

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